Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors

Table 5 Pearson’s correlation coefficients between bone mass parameters, trabecular microarchitecture parameters, and mechanical behavior

	BMD	HU	BVF	Tb.Th	Tb.Sp	DA	Tb.N	Tb.Pf	Conn.D	Failure load
BMD (mg/cm³)
HU	0.74**
BVF (%)	0.76**	0.86**
Tb.Th (µm)	0.55	0.81**	0.82**
Tb.Sp (µm)	− 0.23	− 0.05	− 0.34	− 0.26
DA (n)	− 0.19	− 0.67	− 0.54	− 0.61*	− 0.30
Tb.N (n/mm)	0.60*	0.48	0.71**	0.51	− 0.85**	− 0.01
Tb.Pf(mm⁻¹)	− 0.62*	− 0.84**	− 0.85**	− 0.67*	0.09	0.71**	− 0.54
Conn.D(mm⁻³)	0.43	0.52	0.66*	0.49	− 0.39	− 0.37	0.46	− 0.41
Failure load (N)	0.52	0.70**	0.67*	0.58*	− 0.04	− 0.51	0.46	− 0.81**	0.05
Failure strength (N/mm²)	0.56*	0.86**	0.76**	0.83**	− 0.09	− 0.64*	0.49	− 0.79**	0.19	0.84**

BMD, bone mineral density; HU, Hounsfield units; BVF, bone volume fraction; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation, DA, degree of anisotropy; Tb.N, trabecular number; Tb.Pf, trabecular pattern factor; and Conn.D, connectivity density
^*p < 0.05; **p < 0.01; and ***p < 0.001

ISSN: 1749-799X