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Table 2 Descriptive statistics for microcomputed tomography parameters

From: Breaking strength and bone microarchitecture in osteoporosis: a biomechanical approximation based on load tests in 104 human vertebrae from the cervical, thoracic, and lumbar spines of 13 body donors

  Spinal section Group comparison
Architectural parameter Group Total CS TS LS CS vs. TS
p value
CS vs. LS
p value
TS vs. LS
p value
BVF (%) Total 18.09 ± 2.97 22.79 ± 2.22 17.09 ± 1.17 15.79 ± 0.74 0.023P 0.001P 0.401P
Male 18.95 ± 4.76 26.33 ± 4.81 16.57 ± 1.34 17.27 ± 1.50 0.002P 0.085P 1.000P
Female 17.71 ± 2.53 21.22 ± 1.77 17.33 ± 1.32 15.13 ± 1.22 0.055P 0.001P 0.124P
 ≤ 1Fx 20.43 ± 3.75 25.76 ± 4.28 19.36 ± 1.43 17.66 ± 1.20 0.070P 0.002P 0.196P
 ≥ 2Fx 16.09 ± 2.64 20.24 ± 1.32 15.15 ± 1.43 14.19 ± 0.67 0.015P 0.002P 0.569P
Tb.Th (µm) Total 182 ± 9 191 ± 10 180 ± 6 177 ± 7 0.008L 0.006L 0.477L
Male 184 ± 21 211 ± 19 178 ± 14 171 ± 12 0.001L 0.001L 0.446L
Female 181 ± 7 182 ± 10 181 ± 6 179 ± 7    
 ≤ 1 Fx 189 ± 13 202 ± 16 188 ± 9 179 ± 7 0.026L 0.003L 0.116L
 ≥ 2 Fx 175 ± 9 182 ± 9 172 ± 9 175 ± 9    
Tb.Sp (µm) Total 854 ± 91 729 ± 60 874 ± 59 933 ± 37  < 0.001L  < 0.001L 0.060L
Male 901 ± 152 687 ± 103 969 ± 102 950 ± 90  < 0.001L 0.001L 0.717L
Female 834 ± 91 748 ± 47 831 ± 81 925 ± 61 0.038L 0.001L 0.022L
 ≤ 1 Fx 815 ± 114 683 ± 90 836 ± 99 897 ± 38 0.004L 0.001L 0.206L
 ≥ 2 Fx 888 ± 92 768 ± 52 906 ± 58 963 ± 80 0.001L  < 0.001L 0.098L
DA (n) Total 0.33 ± 0.04 0.29 ± 0.03 0.33 ± 0.04 0.34 ± 0.03    
Male 0.32 ± 0.06 0.28 ± 0.07 0.33 ± 0.05 0.33 ± 0.05    
Female 0.33 ± 0.04 0.30 ± 0.02 0.33 ± 0.04 0.35 ± 0.02    
 ≤ 1 Fx 0.31 ± 0.05 0.28 ± 0.05 0.32 ± 0.05 0.31 ± 0.02    
 ≥ 2 Fx 0.34 ± 0.04 0.31 ± 0.03 0.34 ± 0.04 0.36 ± 0.03    
Tb.N (n/mm) Total 0.87 ± 0.14 1.09 ± 0.09 0.81 ± 0.07 0.78 ± 0.05 0.014P 0.005P 1.000P
Male 0.91 ± 0.21 1.20 ± 0.19 0.79 ± 0.12 0.90 ± 0.12 0.002P 0.293P 0.394P
Female 0.85 ± 0.13 1.04 ± 0.07 0.83 ± 0.08 0.73 ± 0.02 0.037P  < 0.001P 0.114P
 ≤ 1 Fx 1.01 ± 0.19 1.27 ± 0.15 0.94 ± 0.15 0.92 ± 0.06 0.015P 0.051P 1.000P
 ≥ 2 Fx 0.75 ± 0.12 0.94 ± 0.07 0.70 ± 0.05 0.66 ± 0.07 0.015P 0.002P 0.569P
Tb.Pf
(mm−1)
Total 5.91 ± 0.96 4.59 ± 0.60 6.13 ± 0.60 6.69 ± 0.61  < 0.001L  < 0.001L 0.097L
Male 4.95 ± 1.17 3.32 ± 0.94 5.32 ± 0.78 5.69 ± 0.53  < 0.001L  < 0.001L 0.373L
Female 6.33 ± 0.98 5.16 ± 0.47 6.49 ± 0.73 7.13 ± 0.86 0.002L  < 0.001L 0.109L
 ≤ 1 Fx 4.94 ± 1.10 3.56 ± 0.85 5.07 ± 0.78 5.99 ± 0.39 0.001L  < 0.001L 0.030L
 ≥ 2 Fx 6.74 ± 0.92 5.48 ± 0.45 7.04 ± 0.55 7.29 ± 0.86  < 0.001L  < 0.001L 0.449L
Conn.D
(mm−3)
Total 5.60 ± 1.41 7.55 ± 1.29 4.96 ± 0.85 5.19 ± 0.76  < 0.001P 0.001P 0.662P
Male 5.25 ± 2.20 7.44 ± 2.56 3.95 ± 1.05 6.18 ± 1.90 0.001P 0.244P 0.021P
Female 5.76 ± 1.45 7.59 ± 1.38 5.42 ± 1.06 4.75 ± 0.42 0.001P  < 0.001P 0.243P
 ≤ 1 Fx 6.12 ± 1.93 8.03 ± 2.07 5.40 ± 1.67 5.93 ± 1.17 0.008P 0.061P 0.558P
 ≥ 2 Fx 5.16 ± 1.50 7.13 ± 1.32 4.59 ± 1.03 4.55 ± 0.94  < 0.001P 0.001P 0.943P
  1. Values are presented as means ± SD. CS, cervical spine; TS, thoracic spine; LS, lumbar spine; BVF, bone volume fraction; Tb.Th, trabecular bone thickness; Tb.Sp, trabecular separation; DA, degree of anisotropy; Tb.N, trabecular number; Tb.Pf, trabecular pattern factor; Conn.D, connectivity density; Fx, fracture; P, pairwise comparison; and L, post hoc LSD test; in the absence of F test significance, no pairwise comparisons were tested