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Table 2 Subgroup analysis in studies stratified by dosing regimen

From: The preemptive effects of oral pregabalin on perioperative pain management in lower limb orthopedic surgery: a systematic review and meta-analysis

Subgroup No. of comparisons Sample size Mean difference or risk ratio (95% CI) Test for subgroup differences
(Pregabalin/Placebo) (P value)
Static pain intensity at 24 h
 Dosing regimen A 10 280/279 − 0.21 [− 0.41, − 0.00] 0.75
 Dosing regimen B 2 205/96 − 0.12 [− -0.61, 0.37]  
Morphine consumption within 24 h
 Dosing regimen A 6 156/156 − 26.77 [− 44.90, − 8.65] 0.3
 Dosing regimen B 3 274/183 − 53.72 [− 100.88, − 6.57]  
Nausea
 Dosing regimen A 7 260/260 0.70 [0.41, 1.19] 0.84
 Dosing regimen B 5 429/284 0.75 [0.55, 1.02]  
Vomiting
 Dosing regimen A 5 200/200 1.20 [0.81, 1.78] 0.56
 Dosing regimen B 4 348/255 0.86 [0.30, 2.48]  
Dizziness
 Dosing regimen A 4 160/162 1.97 [1.17, 3.32] 0.42
 Dosing regimen B 3 320/228 1.50 [1.00, 2.26]  
Sedation
 Dosing regimen A 2 70/72 1.81 [0.63, 5.18] 0.88
 Dosing regimen B 2 134/136 1.65 [0.99, 2.75]  
  1. Dosing regimen A, receiving pregabalin preoperatively only; Dosing regimen B, receiving pregabalin both pre- and postoperatively