Table 2 Subgroup analysis in studies stratified by dosing regimen
Subgroup | No. of comparisons | Sample size | Mean difference or risk ratio (95% CI) | Test for subgroup differences |
|---|---|---|---|---|
(Pregabalin/Placebo) | (P value) | |||
Static pain intensity at 24 h | ||||
Dosing regimen A | 10 | 280/279 | − 0.21 [− 0.41, − 0.00] | 0.75 |
Dosing regimen B | 2 | 205/96 | − 0.12 [− -0.61, 0.37] | |
Morphine consumption within 24 h | ||||
Dosing regimen A | 6 | 156/156 | − 26.77 [− 44.90, − 8.65] | 0.3 |
Dosing regimen B | 3 | 274/183 | − 53.72 [− 100.88, − 6.57] | |
Nausea | ||||
Dosing regimen A | 7 | 260/260 | 0.70 [0.41, 1.19] | 0.84 |
Dosing regimen B | 5 | 429/284 | 0.75 [0.55, 1.02] | |
Vomiting | ||||
Dosing regimen A | 5 | 200/200 | 1.20 [0.81, 1.78] | 0.56 |
Dosing regimen B | 4 | 348/255 | 0.86 [0.30, 2.48] | |
Dizziness | ||||
Dosing regimen A | 4 | 160/162 | 1.97 [1.17, 3.32] | 0.42 |
Dosing regimen B | 3 | 320/228 | 1.50 [1.00, 2.26] | |
Sedation | ||||
Dosing regimen A | 2 | 70/72 | 1.81 [0.63, 5.18] | 0.88 |
Dosing regimen B | 2 | 134/136 | 1.65 [0.99, 2.75] | |