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Table 1 Characteristics of the included studies

From: The preemptive effects of oral pregabalin on perioperative pain management in lower limb orthopedic surgery: a systematic review and meta-analysis

Studies Origin Anesthesia Sample size Medication plan
Control Pregabalin Preoperative Postoperative
Kheirabadi 2020 Iran Spinal anesthesia 24 26 75-mg 1 h preop Nil
Damirchi 2019 Iran NA 25 25 150-mg 2 h preop Nil
Sebastian 2016 India Spinal anesthesia 45 45 150-mg 1 h preop Nil
Khetarpal 2016 India Spinal anesthesia 30 30 300-mg 1.5 h preop Nil
Akhavanakbari 2013 Iran Spinal anesthesia 30 30 150-mg 2 h preop Nil
Yadeau 2012 USA Spinal anesthesia and peripheral nerve blockade 28 28 100-mg 1 h preop 50-mg pregabalin Bid for 3 days postop
Buvanendran 2010 USA Spinal anesthesia 110 106 300-mg 1–2 h preop 150-mg Bid for days 1–10, 75-mg Bid for days 11 and 12, 50-mg Bid for days 13 and 14 postop
Jain 2012 India Spinal anesthesia 20 20 75-mg 2 h preop 75-mg Bid for 2 days postop
Singla 2015 USA Spinal or epidural anesthesia 104 Arm 1 (n = 103) 75-mg 12 h and 2 h preop 75-mg Bid for 6 weeks postop
Arm 2 (n = 100) 150-mg 12 h and 2 h preop 150-mg Bid for 6 weeks postop
Yadeau 2015 USA Spinal and epidural anesthesia and peripheral nerve blockade 28 Arm 1 (n = 26) 100-mg 30 min preop 50-mg Bid for days 1 to 14, 50-mg Qd for days 15 and 16 postop
Arm 2 (n = 29) 200-mg 30 min preop 100-mg Bid for days 1 to 14, 100-mg Qd for days 15 and 16 postop
Arm 3 (n = 28) 300-mg 30 min preop 150-mg Bid for days 1 to 14, 150-mg Qd for days 15 and 16 postop
Mathiesen 2008 Denmark Spinal anesthesia 38 40 300-mg 1 h before anesthesia Nil
Clarke 2015 Canada Spinal anesthesia 79 83 150-mg 2 h preop 75-mg Bid throughout hospital stay and for 7 days after discharge
Martinez 2014 France General anesthesia 38 Comparison 1 (n = 35) 150-mg 2 h preop Nil
34 Comparison 2 (n = 35) 150-mg 2 h preop, plus intravenous ketamine Nil
Yik 2019 Singapore General anesthesia 42 45 75-mg preop 75-mg Qd for 2 days postop
Rahat 2018 Iran Spinal anesthesia 60 60 150-mg 1 h before anesthesia Nil
Omara 2019 Egypt Spinal anesthesia 30 30 150-mg 1 h preop Nil
Nimmaanrat 2012 Thailand Spinal anesthesia 29 27 75-mg 1 h before anesthesia 75-mg 12 h after the first dose
Lee 2015 Korea General anesthesia 20 21 150-mg 1 h preop Nil
Kavak 2020 Turkey Spinal anesthesia 18 16 150-mg 1 h before anesthesia Nil
Niruthisard 2013 Thailand Spinal anesthesia 27 Comparison 1 (n = 25) 150-mg 2 h preop Nil
24 Comparison 2 (n = 24) 150-mg 2 h preop, plus celecoxib 400-mg Nil
Buvanendran 2012 USA Spinal anesthesia 14 Arm 1 (n = 14) 150-mg 1 h preop Nil
Arm 2 (n = 16) 150-mg 24 h, 12 h and 1 h preop Nil