Table 1 Characteristics of the included studies
Studies | Origin | Anesthesia | Sample size | Medication plan | ||
|---|---|---|---|---|---|---|
Control | Pregabalin | Preoperative | Postoperative | |||
Kheirabadi 2020 | Iran | Spinal anesthesia | 24 | 26 | 75-mg 1 h preop | Nil |
Damirchi 2019 | Iran | NA | 25 | 25 | 150-mg 2 h preop | Nil |
Sebastian 2016 | India | Spinal anesthesia | 45 | 45 | 150-mg 1 h preop | Nil |
Khetarpal 2016 | India | Spinal anesthesia | 30 | 30 | 300-mg 1.5 h preop | Nil |
Akhavanakbari 2013 | Iran | Spinal anesthesia | 30 | 30 | 150-mg 2 h preop | Nil |
Yadeau 2012 | USA | Spinal anesthesia and peripheral nerve blockade | 28 | 28 | 100-mg 1 h preop | 50-mg pregabalin Bid for 3 days postop |
Buvanendran 2010 | USA | Spinal anesthesia | 110 | 106 | 300-mg 1–2 h preop | 150-mg Bid for days 1–10, 75-mg Bid for days 11 and 12, 50-mg Bid for days 13 and 14 postop |
Jain 2012 | India | Spinal anesthesia | 20 | 20 | 75-mg 2 h preop | 75-mg Bid for 2 days postop |
Singla 2015 | USA | Spinal or epidural anesthesia | 104 | Arm 1 (n = 103) | 75-mg 12 h and 2 h preop | 75-mg Bid for 6 weeks postop |
Arm 2 (n = 100) | 150-mg 12 h and 2 h preop | 150-mg Bid for 6 weeks postop | ||||
Yadeau 2015 | USA | Spinal and epidural anesthesia and peripheral nerve blockade | 28 | Arm 1 (n = 26) | 100-mg 30 min preop | 50-mg Bid for days 1 to 14, 50-mg Qd for days 15 and 16 postop |
Arm 2 (n = 29) | 200-mg 30 min preop | 100-mg Bid for days 1 to 14, 100-mg Qd for days 15 and 16 postop | ||||
Arm 3 (n = 28) | 300-mg 30 min preop | 150-mg Bid for days 1 to 14, 150-mg Qd for days 15 and 16 postop | ||||
Mathiesen 2008 | Denmark | Spinal anesthesia | 38 | 40 | 300-mg 1 h before anesthesia | Nil |
Clarke 2015 | Canada | Spinal anesthesia | 79 | 83 | 150-mg 2 h preop | 75-mg Bid throughout hospital stay and for 7 days after discharge |
Martinez 2014 | France | General anesthesia | 38 | Comparison 1 (n = 35) | 150-mg 2 h preop | Nil |
34 | Comparison 2 (n = 35) | 150-mg 2 h preop, plus intravenous ketamine | Nil | |||
Yik 2019 | Singapore | General anesthesia | 42 | 45 | 75-mg preop | 75-mg Qd for 2 days postop |
Rahat 2018 | Iran | Spinal anesthesia | 60 | 60 | 150-mg 1 h before anesthesia | Nil |
Omara 2019 | Egypt | Spinal anesthesia | 30 | 30 | 150-mg 1 h preop | Nil |
Nimmaanrat 2012 | Thailand | Spinal anesthesia | 29 | 27 | 75-mg 1 h before anesthesia | 75-mg 12 h after the first dose |
Lee 2015 | Korea | General anesthesia | 20 | 21 | 150-mg 1 h preop | Nil |
Kavak 2020 | Turkey | Spinal anesthesia | 18 | 16 | 150-mg 1 h before anesthesia | Nil |
Niruthisard 2013 | Thailand | Spinal anesthesia | 27 | Comparison 1 (n = 25) | 150-mg 2 h preop | Nil |
24 | Comparison 2 (n = 24) | 150-mg 2 h preop, plus celecoxib 400-mg | Nil | |||
Buvanendran 2012 | USA | Spinal anesthesia | 14 | Arm 1 (n = 14) | 150-mg 1 h preop | Nil |
Arm 2 (n = 16) | 150-mg 24 h, 12 h and 1 h preop | Nil | ||||