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Table 1 Characteristics of the studies included

From: Kinematic alignment versus mechanical alignment in primary total knee arthroplasty: an updated meta-analysis of randomized controlled trials

References Years Location Study design Sample size Mean age Female Follow-up times (months) Outcomes
KA MA KA MA KA MA
Kaneda [35] 2021 Japan RCT 8 2 76.3 75 NA 5 12 HKA, mLDFA, mMPTA,FFA,TS
Matsumoto [29] 2020 Japan RCT 30 30 74.2 75.5 25 26 12 HKA, mLDFA, mMPTA, KSS, ROM
Young [25] 2020 New Zealand RCT 47 48 NA NA NA NA 60 KSS, WOMAC, OKS, EQ-5D, FJ, Complication
MacDessi [31] 2020 Australia RCT 70 68 67.4 69.0 40 34 12 HKA, mLDFA, mMPTA, KOOS, EQ-5D, FJS, OT
McEwen [28] 2020 New Zealand RCT 41 41 NA NA NA NA 24 HKA, mLDFA, mMPTA, JLOA, FFA,TS, ROM, KOOS, OKS, FJS, Complication
Laende [32] 2019 Canada RCT 24 23 64 63 16 17 24 HKA, mMPTA, OKS
Yeo [26] 2018 South Korea RCT 30 30 72 74 25 27 96 HKA, mLDFA, mMPTA, FFA, TS,WOMAC, ROM
Matsumoto [30] 2017 Japan RCT 30 30 75.3 76.1 18 20 24 HKA, JLOA, KSS, ROM
Waterson [27] 2016 United Kingdom RCT 36 35 NA NA NA NA 12 KSS, ROM, EQ-5D
Calliess [33] 2016 Germany RCT 100 100 67 70 61 57 12 HKA, mLDFA, mMPTA, FFA, TS, WOMAC, Complication
Young [24] 2016 New Zealand RCT 49 50 72 70 24 24 24 HKA, FKA, mLDFA, mMPTA, TS, KSS, WOMAC, ROM, OKS, EQ-5D, FJS, OT, WL, HS, Complication
Belvedere [34] 2015 Italy RCT 6 11 NA NA NA NA 6 KSS
Dossett [20] 2014 United States RCT 44 44 66 66 3 6 24 HKA, FKA, mLDFA, mMPTA, JLOA, KSS, WOMAC, ROM, OKS, HS,CHb,WD, Complication
Dossett [19] 2012 United States RCT 41 41 65 66 2 6 6 HKA, FKA, mLDFA, mMPTA, JLOA, FFA, TS, KSS, WOMAC, ROM, OKS, Complication, OT, WL, HS, CHb, WD
  1. KA kinematic alignment, MA mechanical alignment, HKA hip–knee–ankle angle, FKA femoral knee angle, mLDFA mechanical lateral distal femoral angle, mMPTA mechanical medial proximal tibial angle, JLOA joint line orientation angle, FFA femoral flexion–extension angle, TS tibial slope, KSS knee society score, KOOS Knee Injury and Osteoarthritis Outcome Score, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, OKS Oxford Knee Score, EQ-5D EuroQoL 5-dimension questionnaire, FJS Forgotten Joint Score, ROM range of motion, OT operative time, WL wound length, HS hospital stay, CHb change in hemoglobin, WD walking distance, NA not applicable, RCT randomized controlled clinical trials