Author | Title | Year | Region | Age | Gender | BMI | Study design |
---|---|---|---|---|---|---|---|
Pinsornsak P | Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial | 2016 | Thailand | PAI 67.63 IV 69.97 | PAI 5M/25F IV 7M/23F | PAI 27.96 IV 26.52 | A randomized controlled trial |
Mao Z | A comparative, retrospective study of peri-articular and intra-articular injection of tranexamic acid for the management of postoperative blood loss after total knee arthroplasty | 2016 | China | PAI 68.5 IA 69.7 Non-TXA 69.6 | PAI 8M/41F IA 5M/31F Non-TXA 10M/32F | PAI 25.9 IA 25.6 Non-TXA 26.6 | A retrospective study |
Yozawa S | Periarticular injection of tranexamic acid reduces blood loss and the necessity for allogeneic transfusion after total knee arthroplasty using autologous transfusion: a retrospective observational study | 2017 | Japan | PAI 75.1 Non-TXA 73.0 | PAI 13M/31F Non-TXA 10M/34F | PAI 26.4 Non-TXA 26.0 | A retrospective study |
Zhang S | Multi-route applications of tranexamic acid to reduce blood loss after total knee arthroplasty: a randomized controlled trial | 2019 | China | PAI 66 IA 68.5 PAI + IA 66 Non-TXA 68 | PAI 16M/37F IA 14M/38F PAI + IA 11M/39F Non-TXA 12M/43F | PAI 25.98 IA 25.32 PAI + IA 25.52 Non-TXA 25.28 | A randomized controlled trial |
Besiris GT | Topical use of tranexamic acid in primary total knee arthroplasty: a comparative study | 2020 | Greece | PAI 72.08 IA 72.27 | NR | NR | A observational prospective comparative study |
Lin YK | Significantly reducing blood loss via a peri-articular injection of tranexamic acid during total knee arthroplasty: a retrospective study | 2021 | China | 70.46 | 18M/32F | 27.65 | A retrospective study |
Sivasubramanian H | Local infiltration of analgesia and tranexamic acid is safe and efficacious in reducing blood loss and comparable to intra-articular tranexamic acid in total knee replacements | 2021 | Singapore | PAI 65.5 IA 66.8 | PAI 9M/12F IA 20M/22F | PAI 20.6 IA 21.5 | A retrospective study |
Pinsornsak P | Efficacy and systemic absorption of peri-articular versus intra-articular administration of tranexamic acid in total knee arthroplasty: a prospective randomized controlled trial | 2021 | Thailand | PAI 65.6 IA 68.4 Non-TXA 68.6 | PAI 2M/34F IA 3M/33F Non-TXA 4M/32F | PAI 27.4 IA 26.9 Non-TXA 25.6 | A prospective randomized controlled trial |
Peng HM | Multimodal Peri-articular Injection with Tranexamic Acid can reduce postoperative blood loss versus intravenous tranexamic acid in total knee arthroplasty: a randomized controlled trial | 2021 | China | PAI 68.65 IV 68.13 | PAI 7M/39F IV 6M/41F | PAI 26.81 IV 27.06 | A randomized controlled trial |
Kim KI | Tranexamic acid in a periarticular multimodal cocktail injection for blood management in total knee arthroplasty: a prospective randomized study | 2021 | Korea | IV 72.08 PAI 72.58 PAI + IV 72.35 | IV 13M/67F PA 13M/67F PAI + IV 11M/69F | IV 26.36 PAI 26.54 PAI + IV 26.05 | A prospective randomized study |