Fig. 1

Expression of miRNA-4701-5p and HMGA1 in IL-1β induced CHON-001 cells. CHON-001 cells were exposed to 10 ng/ml IL-1β for 12 h. A CHON-001 cells proliferation was assessed by MTT assay. B The cytotoxicity of CHON-001 cells was accessed by LDH quantification. C, D Flow cytometry analysis of apoptotic cell. E, F Detection of cleaved-caspase3 expressions. G–I The secretion of IL-6, IL-8 and TNF-α in the supernatant of CHON-001 cells was determined by ELISA. J qRT-PCR analysis of miRNA-4701-5p level. K, L Western blot and qRT-PCR analysis of HMGA1 expression. **p < 0.01 versus control