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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Cyclic mechanical strain with high-tensile triggers autophagy in growth plate chondrocytes

Fig. 4

CTS promoted the formation of autophagic vacuoles in GPCs. A Representative images in nonstretched GPCs, GPCs received CTS (5500 με, 2.0 Hz) for 30 min, GPCs received CTS (5500 με, 2.0 Hz) for 2 h, and GPCs received CTS (5500 με, 2.0 Hz) for 2 h together with 3MA (10 mM). Black arrows indicate the autophagosome or early autophagic vacuole (AVi), and white arrows indicate the autolysosome or degradative autophagic vacuole (AVd). B Statistical diagram of the number of autophagic vacuoles (AVs, including AVi and AVd) in each group. Data were expressed as Mean ± SD, n = 3, *P < 0.05, **P < 0.005, ***P < 0.001

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