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Table 3 Genetic variants derived from eligible meta-analyses of steroid-induced FHON

From: Integrative analyses of genes related to femoral head osteonecrosis: an umbrella review of systematic reviews and meta-analyses of observational studies

Genetic variant

Gene (or near gene)

Reference (year of data collection)

Ethnicity

Sample size (case/control)

Included studies

Minor allele & major allele

Genetic model

Type of model

Reported OR (95% CI)

p value for genetic main effect

Heterogeneity (%)

Venice criteria

Evidence class

rs693

ApoB

Chen et al. [35]

Mixed

570 (total)

4

C & T

Allelic model

NA

2.63 [0.92–7.53]

0.072

58.00

NA

NA

Heterozygous model

NA

2.46 [1.27–4.77]

0.008

54.50

NA

NA

Homozygous model

NA

7.70 [1.23–48.18]

0.029

24.40

NA

NA

Recessive model

NA

7.16 [1.19–43.05]

0.031

32.10

NA

NA

rs693

ApoB

Chen et al. [35]

Mixed

725 (total)

5

C & T

Dominant model

NA

2.99 [1.71–5.22]

 < 0.001

31.30

BBB

Moderate

rs1042031

ApoB

Chen et al. [35]

Mixed

572 (total)

4

G & A/C

Dominant model

NA

2.90 [1.49–5.65]

0.002

50.30

BCB

Weak

rs1042031

ApoB

Chen et al. [35]

China

415 (total)

3

G & A/C

Dominant model

NA

4.81 [2.05–11.30]

 < 0.001

0

BAB

Moderate

rs1801133

MTHFR

Chen et al. [35]

Mixed

251 (total)

3

C & T

Allelic

NA

0.92 [0.59–1.44]

0.710

12.90

NA

NA

Heterozygous model

NA

0.62 [0.33–1.17]

0.144

22.10

NA

NA

Homozygous model

NA

1.24 [0.48–3.21]

0.653

0

NA

NA

Recessive model

NA

1.54 [0.63–3.76]

0.339

0

NA

NA

507 (total)

4

C & T

Dominant model

NA

0.94 [0.61–1.45]

0.775

23.40

NA

NA

rs1045642

ABCB1

Zhou et al. [36]

Asian/mixed

336/712

7

T & C

Allelic

Fixed effect

0.68 [0.54–0.84]

0.295

18.30

NA

NA

Heterozygous model

Fixed effect

0.73 [0.53–1.00]

0.722

0

NA

NA

Homozygote model

Random effect

0.43 [0.26–0.69]

0.049

58.10

NA

NA

Recessive model

Random effect

0.52 [0.34–0.81]

0.009

70.30

NA

NA

Dominant model

Fixed effect

0.64 [0.48–0.87]

0.830

0

NA

NA

rs2032582

ABCB1

Zhou et al. [36]

Mixed

275/574

5

T/A &G

Allelic

Fixed effect

0.73 [0.58–0.90]

0.587

0

NA

NA

Heterozygous model

Fixed effect

0.66 [0.45–0.96]

0.985

0

NA

NA

Homozygote model

Fixed effect

0.52 [0.34–0.82]

0.560

0

NA

NA

Recessive model

Fixed effect

0.71 [0.49–1.01]

0.385

3.9

NA

NA

Dominant model

Fixed effect

0.61 [0.43–0.87]

0.959

0

NA

NA

rs1799889

PAI-1

Gong et al. [37]

Mixed

108/917

4

4G/5G

Allele model

NA

1.93 [1.15–3.26]

0.014

0.0004 (P)

NA

NA

Homozygote model

NA

3.22 [1.67–6.21]

 < 0.0005

0.00111 (P)

ACB

Moderate

Dominant model

NA

2.31 [1.53–3.49]

 < 0.0005

0.06 (P)

ACB

Moderate

Recessive model

NA

2.30 [1.24–4.30]

0.009

0.162 (P)

NA

NA

  1. The signature of bold represents OR, p value, and heterogeneity of genetic variances with a p value < 0.05
  2. Evidence is classified as strong, moderate, and weak. When scored A in every criteria, evidence is categorized as strong. When scored no C in every criteria but no AAA, evidence is categorized as moderate. Weak evidence is recorded with C in one out of three criteria