Genetic variant | Gene (or near gene) | Reference (year of data collection) | Ethnicity | Sample size (case/control) | Included studies | Minor allele & major allele | Genetic model | Type of model | Reported OR (95% CI) | p value for genetic main effect | Heterogeneity (%) | Venice criteria | Evidence class |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs693 | ApoB | Chen et al. [35] | Mixed | 570 (total) | 4 | C & T | Allelic model | NA | 2.63 [0.92–7.53] | 0.072 | 58.00 | NA | NA |
Heterozygous model | NA | 2.46 [1.27–4.77] | 0.008 | 54.50 | NA | NA | |||||||
Homozygous model | NA | 7.70 [1.23–48.18] | 0.029 | 24.40 | NA | NA | |||||||
Recessive model | NA | 7.16 [1.19–43.05] | 0.031 | 32.10 | NA | NA | |||||||
rs693 | ApoB | Chen et al. [35] | Mixed | 725 (total) | 5 | C & T | Dominant model | NA | 2.99 [1.71–5.22] |  < 0.001 | 31.30 | BBB | Moderate |
rs1042031 | ApoB | Chen et al. [35] | Mixed | 572 (total) | 4 | G & A/C | Dominant model | NA | 2.90 [1.49–5.65] | 0.002 | 50.30 | BCB | Weak |
rs1042031 | ApoB | Chen et al. [35] | China | 415 (total) | 3 | G & A/C | Dominant model | NA | 4.81 [2.05–11.30] |  < 0.001 | 0 | BAB | Moderate |
rs1801133 | MTHFR | Chen et al. [35] | Mixed | 251 (total) | 3 | C & T | Allelic | NA | 0.92 [0.59–1.44] | 0.710 | 12.90 | NA | NA |
Heterozygous model | NA | 0.62 [0.33–1.17] | 0.144 | 22.10 | NA | NA | |||||||
Homozygous model | NA | 1.24 [0.48–3.21] | 0.653 | 0 | NA | NA | |||||||
Recessive model | NA | 1.54 [0.63–3.76] | 0.339 | 0 | NA | NA | |||||||
507 (total) | 4 | C & T | Dominant model | NA | 0.94 [0.61–1.45] | 0.775 | 23.40 | NA | NA | ||||
rs1045642 | ABCB1 | Zhou et al. [36] | Asian/mixed | 336/712 | 7 | T & C | Allelic | Fixed effect | 0.68 [0.54–0.84] | 0.295 | 18.30 | NA | NA |
Heterozygous model | Fixed effect | 0.73 [0.53–1.00] | 0.722 | 0 | NA | NA | |||||||
Homozygote model | Random effect | 0.43 [0.26–0.69] | 0.049 | 58.10 | NA | NA | |||||||
Recessive model | Random effect | 0.52 [0.34–0.81] | 0.009 | 70.30 | NA | NA | |||||||
Dominant model | Fixed effect | 0.64 [0.48–0.87] | 0.830 | 0 | NA | NA | |||||||
rs2032582 | ABCB1 | Zhou et al. [36] | Mixed | 275/574 | 5 | T/A &G | Allelic | Fixed effect | 0.73 [0.58–0.90] | 0.587 | 0 | NA | NA |
Heterozygous model | Fixed effect | 0.66 [0.45–0.96] | 0.985 | 0 | NA | NA | |||||||
Homozygote model | Fixed effect | 0.52 [0.34–0.82] | 0.560 | 0 | NA | NA | |||||||
Recessive model | Fixed effect | 0.71 [0.49–1.01] | 0.385 | 3.9 | NA | NA | |||||||
Dominant model | Fixed effect | 0.61 [0.43–0.87] | 0.959 | 0 | NA | NA | |||||||
rs1799889 | PAI-1 | Gong et al. [37] | Mixed | 108/917 | 4 | 4G/5G | Allele model | NA | 1.93 [1.15–3.26] | 0.014 | 0.0004 (P) | NA | NA |
Homozygote model | NA | 3.22 [1.67–6.21] |  < 0.0005 | 0.00111 (P) | ACB | Moderate | |||||||
Dominant model | NA | 2.31 [1.53–3.49] |  < 0.0005 | 0.06 (P) | ACB | Moderate | |||||||
Recessive model | NA | 2.30 [1.24–4.30] | 0.009 | 0.162 (P) | NA | NA |