Table 1 Description of the extension of the Human Genome Epidemiology Network’s Venice criteria to assess genetic main effect
Criteria of consideration | Category | Proposed operationalization |
|---|---|---|
Amount of evidence | A | Sample size over 1000 |
B | Sample size 100–1000 | |
C | Sample size under 100 | |
Replication | A | I2 < 50% |
B | 25% < I2 < 50% | |
C | I2 > 50% | |
Protection from bias | A | Consideration biases such as bias in genotyping, population stratification, and Selective reporting biases |
B | Bias in genotype definition = Not reported what was done/No quality control checks/Appropriate quality control checks | |
C | Population stratification = Not reported what was done/Nothing done/Same descent group/Adjustment for reported descent/Family-based design/Genomic control, PCA or similar method Selective reporting biases = Meta-analysis of published data/Retrospective efforts to include unpublished data/Meta-analysis within consortium |