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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: Potential of RNA-binding protein human antigen R as a driver of osteogenic differentiation in osteoporosis

Fig. 7

Overexpression of HuR ameliorated osteoporosis-related phenotypes in OVX mice. a A graph illustrating animal model and treatment. b Morphology of femur tissues of sham-operated mice, untreated OVX mice, or OVX mice treated with oe-HuR scanned by micro-CT. C-I, Quantitative analysis of BV/TV (c), BS/BV (d), Tb.Sp (e), Tb.Th (f), Tb.N (g), Conn.D (h), and structural model index (SMI) (i) in sham-operated mice, untreated OVX mice, or OVX mice treated with oe-HuR by micro-CT scan. j HE staining to observe the osteogenic differentiation in sham-operated mice, untreated OVX mice, or OVX mice treated with oe-HuR. k–n Detection of mRNA expression of osteogenic differentiation-related factors Runx2 (k), OCN (l), OPN (m), COL1 (n) in bone tissues of sham-operated mice, untreated OVX mice, or OVX mice treated with oe-HuR by RT-qPCR. *p < 0.05 versus sham-operated mice, # p < 0.05 vs. Untreated OVX mice. Measurement data were expressed as mean ± standard deviation. Data comparison among multiple groups was conducted by one-way ANOVA, followed by Tukey’s post hoc test. n = 12

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