Fig. 5

Downregulation of miR-145-5p reversed the suppressive effects of circ_0001017 knockdown on cell proliferation, migration and invasion in OS cells. A Quantitative real-time PCR was used to determine the expression level of miR-145-5p in U2OS cells after transfection with miR-145-5p inhibitor or miR-NC. **p < 0.01, compared with miR-NC; B MTT assay, C flow cytometry and D, E transwell assay were performed to evaluate cell proliferation, apoptosis, migration and invasion in U2OS cells after co-transfection with miR-145-5p inhibitor and si-circ_0001017. ***p < 0.001, compared with si-NC + miR-NC; ##p < 0.01, ###p < 0.001, compared with si-circ_0001017 + miR-NC