Fig. 1

Overview of differential expressed circRNAs and mRNAs in OS. A, B Hierarchical clustering of differential expressed circRNAs (A) and mRNAs (B) in OS. Each row represents a circRNA or mRNA and each column represents an OS or control sample. Red or green colors represent high or low relative expression level, respectively. C, D Volcano plot of circRNA and mRNA expression. Each point represents a circRNA or mRNA. The red points indicate significantly differential expressed (fold-change > 2.0) circRNAs or mRNAs. RNAs were extracted from OS and matched adjacent tissues of four patients with OS