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Table 2 Univariate logistics and multivariate Cox regression analysis for risk factors of lymph node metastasis

From: Risk factors for lymph node metastasis of soft tissue sarcomas of the head, neck, and extremities, and the clinical significance of negative lymph node dissection

Variables

Univariate analysis

Multivariate analysis

OR (95% CI)

p value

OR (95% CI)

p value

Age, years

 < 19

Reference

 

Reference

 

 ≥ 19

0.198 (0.153–0.256)

< 0.001

0.927 (0.681–1.263)

0.633

Race

 White

Reference

 

Reference

 

 Black

1.793 (1.272–2.529)

0.001

1.293 (0.933–1.791)

0.123

 Other

1.37 (0.885–2.122)

0.158

1.044 (0.687–1.585)

0.841

Sex

 Female

Reference

 

Reference

 

 Male

1.289 (1.002–1.659)

0.048

1.291 (1.012–1.646)

0.040

Site

 Head, Face, Neck

Reference

 

Reference

 

 Upper limb, shoulder

0.625 (0.453–0.861)

0.004

0.549 (0.345–0.876)

0.012

 Lower limb, hip

0.411 (0.308–0.548)

< 0.001

0.394 (0.249–0.626)

< 0.001

Grade

 I + II

Reference

 

Reference

 

 III + IV

8.708 (4.032–18.806)

< 0.001

3.93 (1.805–8.554)

0.001

 Unknown

14.788 (6.901–31.691)

< 0.001

5.033 (2.325–10.895)

 < 0.001

Laterality

 Left

Reference

 

Reference

 

 Right

1.235 (0.933–1.634)

0.14

1.196 (0.912–1.57)

0.196

 Unknown

2.018 (1.455–2.798)

 < 0.001

0.792 (0.494–1.27)

0.334

Histology

 Leiomyosarcoma

Reference

 

Reference

 

 Rhabdomyosarcoma

25.435 (15.906–40.673)

< 0.001

9.598 (5.719–16.11)

< 0.001

 Angiosarcoma

6.621 (3.845–11.401)

< 0.001

5.459 (3.163–9.419)

< 0.001

 Ewing sarcoma

7.921 (4.365–14.377)

< 0.001

4.026 (2.205–7.351)

< 0.001

 Epithelioid sarcoma

10.671 (5.917–19.247)

< 0.001

7.965 (4.435–14.307)

< 0.001

 Clear cell sarcoma

15.14 (8.241–27.817)

< 0.001

11.587 (6.397–20.989)

< 0.001

Size, cm

 < 4

Reference

 

Reference

 

 4–10

2.351 (1.732–3.191)

< 0.001

2.08 (1.521–2.845)

< 0.001

 ≥ 10

3.032 (2.155–4.267)

< 0.001

4.676 (3.25–6.728)

< 0.001

  1. OR odds ratio, CI confidence interval
  2. Bold values mean p value < 0.05, which represent statistically significant