Fig. 4

Role of PRNCR1 and miR-377-3p in the proliferation and apoptosis of OA synoviocytes. OA synoviocytes were treated with 0, 3, 9, 12, and 15 μg/ml LPS (Sigma-Aldrich) for 48 h, and PRNCR1 expression (A) and miR-377-3p expression (B) was analyzed using RT-qPCR after RNA isolation. The role of PRNCR1 and miR-377-3p in regulating the proliferation (C) and apoptosis of synoviocytes induced by LPS (D) were analyzed using cell proliferation and apoptosis analyses. IL-1β expression level was analyzed using qRT-PCR (E). *p < 0.05