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Table 4 The peri-operative values of FDP, D-D, PT, and APTT

From: Not all patients benefit from the postoperative antifibrinolytic treatment: clinical evidence against the universal use of tranexamic acid following total knee arthroplasty

Outcomes

NFSD (n = 95)

FSD (n = 175)

Group A (n = 49)

Group B (n = 46)

p

Group A (n = 63)

Group B (n = 112)

p

FDP ± SD (μg/mL)

 Pre-OP

3.38 ± 5.38

2.20 ± 3.18

0.290*

2.91 ± 4.64

2.27 ± 4.35

0.436*

 POD1

19.13 ± 17.82

15.32 ± 11.68

0.314*

21.86 ± 25.87

16.70 ± 10.61

0.209*

 POD3

6.82 ± 2.72

6.57 ± 4.72

0.796*

7.29 ± 4.91

7.17 ± 4.58

0.889*

 POD5

11.53 ± 6.58

8.41 ± 3.34

0.139*

11.74 ± 6.02

10.98 ± 4.53

0.597*

 POD7

13.99 ± 5.70

12.41 ± 3.97

0.422*

13.69 ± 4.34

13.60 ± 5.92

0.963*

D-D ± SD (mg/L)

 Pre-OP

1.21 ± 2.08

0.70 ± 0.86

0.218*

1.08 ± 1.77

0.84 ± 1.65

0.462*

 POD1

8.16 ± 7.73

5.73 ± 3.99

0.125*

6.40 ± 3.79

6.14 ± 5.55

0.777*

 POD3

2.54 ± 2.69

2.22 ± 1.13

0.554*

2.82 ± 2.82

2.47 ± 1.89

0.474*

 POD5

4.82 ± 4.03

3.23 ± 1.86

0.213*

4.90 ± 3.45

4.31 ± 1.94

0.465*

 POD7

5.61 ± 1.85

5.17 ± 2.65

0.593

5.08 ± 3.64

5.02 ± 1.37

0.953*

PT ± SD (s)

 Pre-OP

13.34 ± 0.78

13.25 ± 0.67

0.594*

13.24 ± 0.69

13.10 ± 0.81

0.322*

 POD1

13.80 ± 1.12

13.98 ± 0.80

0.406*

13.98 ± 1.63

13.89 ± 0.77

0.650*

 POD3

13.69 ± 0.88

13.79 ± 0.84

0.631*

13.47 ± 1.91

13.72 ± 1.02

0.301*

 POD5

13.56 ± 1.01

13.51 ± 0.83

0.875*

13.22 ± 0.98

13.35 ± 0.86

0.565*

 POD7

13.52 ± 0.51

13.55 ± 0.62

0.876*

12.76 ± 1.93

12.89 ± 0.72

0.810*

APTT ± SD (s)

 Pre-OP

35.38 ± 4.29

37.76 ± 9.94

0.228*

35.40 ± 3.78

35.85 ± 3.59

0.496*

 POD1

36.11 ± 3.07

36.63 ± 4.05

0.558*

35.49 ± 3.83

35.42 ± 3.22

0.902*

 POD3

38.57 ± 4.36

39.76 ± 6.85

0.416*

38.41 ± 4.64

38.52 ± 4.96

0.903*

 POD5

37.93 ± 8.42

39.21 ± 4.50

0.494*

38.59 ± 4.81

37.83 ± 5.48

0.570*

 POD7

35.14 ± 4.59

37.82 ± 4.14

0.108*

37.80 ± 4.23

36.71 ± 5.57

0.546*

  1. NFSD non-fibrinolytic shutdown, FSD fibrinolytic shutdown, FDP fibrin degradation product, SD standard deviation, Pre-OP preoperative, POD postoperative day, D-D D-dimer, PT prothrombin time, APTT activated partial thromboplastin time
  2. *Independent-samples t test
  3. Mann–Whitney U test