Fig. 4

Circ_0001947 regulated RA-FLS progression by sponging miR-671-5p. RA-FLSs were transfected with si-NC, si-circ_0001947, si-circ_0001947 + anti-miR-NC or si-circ_0001947 + anti-miR-671-5p. A The expression of miR-671-5p in RA-FLSs was detected by qRT-PCR. B–D The proliferation of RA-FLSs was examined via CCK-8 assay and EdU assay. E–G The apoptosis, invasion and migration of RA-FLSs were estimated by flow cytometry analysis, transwell assay and wound-healing assay, respectively. H The protein levels of CyclinD1 and MMP9 in RA-FLSs were measured by western blot assay. I The concentrations of TNF-α and IL-1β in RA-FLSs were examined by ELISA kits. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001