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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis

Fig. 2

Effects of circ_0001947 on RA-FLS cell growth, apoptosis, invasion, migration and inflammation. RA-FLSs were introduced with si-NC or si-circ_0001947. A The expression of circ_0001947 in RA-FLSs was examined by qRT-PCR. B, C The proliferation of RA-FLSs was estimated by CCK-8 assay and EdU assay. D The apoptosis of RA-FLSs was analyzed by flow cytometry analysis. E, F The invasion and migration of RA-FLSs were assessed by transwell assay and wound-healing assay. G The protein levels of Cyclin D1 and MMP9 in RA-FLSs were measured via western blot assay. H The concentrations of TNF-α and IL-1β in RA-FLSs were examined by ELISA. **P < 0.01, ***P < 0.001, ****P < 0.0001

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