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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: 5-ALA-mediated fluorescence of musculoskeletal tumors in a chick chorio-allantoic membrane model: preclinical in vivo qualification analysis as a fluorescence-guided surgery agent in Orthopedic Oncology

Fig. 3

PDD/PDT and histopathological results—bone tumors. C18—chondrosarcoma high-grade. PDD only. Fluorescence +. Arrow highlights vital tumor areas in a specimen classified as viable. C22—chondrosarcoma high-grade. PDT. Fluorescence ++. Arrow highlights areas with regressive changes in a specimen classified as partially regressive. E58—pleomorphic bone sarcoma high-grade. PDD only. Fluorescence ++. Predominantly vital tumor areas in a specimen classified as viable. F13—atypical chondrogenic tumor. PDD only. Fluorescence ++. Arrow highlights residual vital tumor areas in a specimen classified as regressive. F53—Giant cell tumor of bone. PDD only. Fluorescence ++. Arrow highlights areas with necrosis and regressive changes in a specimen classified as regressive. F51—giant cell tumor of bone. PDT. Fluorescence ++. Arrow highlights areas with hemorrhage and regressive changes in a specimen classified as regressive. N37—chordoma (primary cell culture). PDD only. Fluorescence negative. Arrow highlights vital tumor clusters (in matrigel) in a specimen classified as viable. N43—dedifferentiated chondrosarcoma (primary cell culture). PDD only. Fluorescence +. Arrow highlights vital tumor cell with an atypical mitosis (in matrigel) in a specimen classified as viable

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X