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Table 2 Details of intervention procedure parameters, results, adverse effects, and follow-up time of the 15 RCTs included in the current meta-analysis

From: Efficacy and safety of radiofrequency treatment for improving knee pain and function in knee osteoarthritis: a meta-analysis of randomized controlled trials

References

Intervention

Control

Treatment target

Intervention parameters

Diagnostic nerve block

Scoring methods

Adverse effects

Follow-up time (weeks)

[21]

RFA

Shame-RFA

GN

70 °C, 90 s

Yes

VAS, GPE, OKS

None reported

1, 4,12

[22]

RFA

Intra-articular injection of sodium hyaluronate

GN

70 °C, 120 s

No

VAS

None reported

1, 4, 12

[23]

PRF

Intra-articular injection of dextrose

IA

42 °C, 15 min

No

VAS

None reported

1, 4,12

[24]

RFA

Intra-articular injection of sodium hyaluronate

GN

70 °C, 120 s

No

VAS, OKS

None reported

1, 4,12

[25]

RFA

Intra-articular injection of platelet-rich plasma and sodium hyaluronate

IA

70 °C, 120 s

No

VAS

NA

1, 12

[35]

PRF

Intra-articular injection of lidocaine and betamethasone

IA

42 °C, 120 s

Yes

VAS, WOMAC

None reported

1, 4, 12, 24

[26]

RFA

Intra-articular injection of bupivacaine, morphine, and betamethasone

GN

80 °C, 90 s

No

WOMAC

NA

4, 12

[27]

PRF

Oral celecoxib

IA

42 °C, 120 s

No

VAS, WOMAC

NA

4, 24

[28]

RFA

Intra-articular injection of sodium hyaluronate

GN

60, 70, and 80˚C, 90 s

No

VAS

NA

1, 12, 24

[29]

RFA

Oral paracetamol and NAIDS

GN

80 °C, 270 s

No

VAS, WOMAC

None reported

1, 12, 24

[30]

CRF

Intra-articular steroid

GN

60 °C, 150 s

Yes

NRS, OKS

34/30

4, 12, 24

[31]

CRMRF

Shame-CRMRF

IA

15 min

No

VAS

None reported

1, 4,12

[32]

CRF

Intra-articular injection of sodium hyaluronate

IA

60 °C, 150 s

Yes

GPE, WOMAC

18/9

4, 12, 24

[33]

RF thermocoagulation

Intra-articular steroid

GN

70 °C, 120 s

No

GPE

None reported

1, 4, 12, 24

[34]

PRF

Shame-PRF

IA

42 °C, 120 s

Yes

NRS, OKS

None reported

1, 4, 12, 24

  1. RFA, radiofrequency ablation; PRF, pulsed radiofrequency ablation; CRF, cooled radiofrequency ablation; CRMRF, capacitive resistive monopolar radiofrequency; NSAIDs, nonsteroidal anti-inflammatory drugs; GN, genicular nerve; IA, intra-articular; VAS, Visual Analogue Scale; GPE, Global Perceived Effect; WOMAC, Western Ontario and McMaster Universities; OKS, Oxford Knee Scores; NA, not applicable