Impact of tourniquet during total knee arthroplasty when tranexamic acid was used: a meta-analysis of randomized controlled trials

Sun, Changjiao; Zhang, Xiaofei; Ma, Qi; Tu, Yan; Cai, Xu; Zhou, Yonggang

doi:10.1186/s13018-021-02898-1

Journal of Orthopaedic Surgery and Research

Table 4 The detailed information of TXA and Thromboprophylaxis drugs

From: Impact of tourniquet during total knee arthroplasty when tranexamic acid was used: a meta-analysis of randomized controlled trials

Author/year	TXA administration	Thromboprophylaxis drugs
Alexandersson 2018	Intravenously, 1 g, 10 min before surgery	Low-molecular weight heparin
Concina 2019	Intravenously, 15 mg/kg, 20 min before surgery and after 4 h	Enoxaparine 4000 IU
Ejaz 2014	Orally, 1 g, before surgery; orally, 0.5 g 3 h after surgery	Rivaroxaban (10 mg/day)
Huang 2017	Intravenously, 20 mg/kg, 5 to 10 min before the skin incision; Intravenous, 10 mg/kg, 3, 6, 12, and 24 h after operation; Topical, 1 g, intraoperatively	Enoxaparine 4000 IU
Ma 2017	Intravenously, 20 mg/kg, anesthesia induction; Topical, 1 g, intraoperatively; Intravenous, 10 mg/kg, 3, 6, 12, 24 h after anesthesia induction	Enoxaparine 4000 IU
Palanne 2020¹	Intravenously, 1 g, 5 min before surgery; Topical, 1 g, intraoperatively; 1 g, 3 h, 6 h after surgery	NA
Palanne 2020²	Intravenously, 1 g, 5 min before surgery; Topical, 1 g, intraoperatively; 1 g, 3 h, 6 h after surgery	NA
Wang 2017	Intravenously, 1 g, 15 min before surgery; Topical, 1 g, intraoperatively	Rivaroxaban (10 mg/day)
Wang 2019	Intravenously, 1 g, 15 min before surgery; Topical, 1 g, intraoperatively; Intravenously, 1 g, 3 h after surgery	Enoxaparine 4000 IU
Xie 2017	Intravenously, 20 mg/kg, 10 min before surgery; Topical, 60 ml, intraoperatively	Enoxaparine 4000 IU
Xue 2018	Intravenously, 1 kg, 30 min before surgery	Rivaroxaban (10 mg/day)
Yu 2017	Topical, 1 g, intraoperatively	Rivaroxaban (10 mg/day)
Zak 2021	Intravenously, two dose of 1 g, before surgery and during wound closure	NA
Zeng 2021	Intravenously, 1 kg, before surgery	Rivaroxaban (10 mg/day)
Zhou 2017	Intravenously, 1 g, at the initiation of the surgery and just before closure	Rivaroxaban (10 mg/day)

The detailed information of TXA and thromboprophylaxis drugs of two groups. h, hour; min, minute; IU, international unit; kg, kilogram; g, gram; mg, milligram; ml, milliliter

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ISSN: 1749-799X

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