Table 3 Subgroup analysis of CLP for PJI diagnosis
From: Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysis
Subgroup analyses | No. of studies | Sensitivity (95% CI) | I2 (95% CI) | Specificity (95%CI) | I2 (95% CI) | PLN (95% CI) | NLR (95% CI) | Diagnostic score (95% CI) | DOR (95% CI) | AUC (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
Overall studies | 7 | 0.94(0.87–0.98) | 71.11(48.63–93.58) | 0.93(0.87–0.96) | 76.9(59.85–93.95) | 13.65(6.89–27.08) | 0.06(0.02–0.15) | 5.40(3.96–6.85) | 222.33(52.52–941.11) | 0.98(0.96–0.99) |
Prospective | 6 | 0.96 (0.91–0.98) | 24.21(0.00–89.32) | 0.95(0.91–0.97) | 0.00(0.00–100.00) | 17.56 (10.49–29.38) | 0.05 (0.02,0.10) | 5.94(4.95–6.93) | 378.51(140.62–1018.79) | 0.98(0.96–0.99) |
Detection method | ||||||||||
Lateral flow assay | 4 | 0.91(0.76–0.97) | 71.26(41.15–100.00) | 0.9(0.80–0.95) | 77.92(55.97–99.88) | 9.09(4.01–20.61) | 0.10(0.04–0.30) | 4.49(2.74–6.23) | 88.72(15.44–509.81) | 0.96(0.94–0.97) |
ELISA | 4 | 0.97(0.93–0.99) | 0.00(0.00–10.00) | 0.96(0.92–0.98) | 0.00(0.00–10.00) | 23.83(12.08–47.01) | 0.03(0.01–0.07) | 6.73(5.51–7.95) | 840.12(248.09–2845.01) | 0.99(0.98–1.00) |
Sample size | ||||||||||
< 100 | 6 | 0.93(0.83–0.97) | 66.87(38.12–95.63) | 0.93(0.85–0.96) | 77.50(59.56–95.44) | 12.47(5.83–26.65) | 0.08(0.03–0.19) | 5.09(3.57–6.61) | 162.99(35.64–745.50) | 0.97(0.96–0.98) |
Cutoff values | ||||||||||
50 mg/L | 5 | 0.94(0.81–0.98) | 76.58(55.75–97.41) | 0.91(0.83–0.96) | 78.20(59.12–97.28) | 10.97(5.05–23.85) | 0.07(0.02–0.23) | 5.07(3.24–6.91) | 159.59(25.54–997.40) | 0.97(0.95–0.98) |