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Table 3 Pooled odds ratios of VEGF on clinicopathologic features in osteosarcoma

From: The role of vascular endothelial growth factor as a prognostic and clinicopathological marker in osteosarcoma: a systematic review and meta-analysis

Variables

No. of studies

Heterogeneity test

Effect size

Model

Conclusion

I2 (%)

p value

OR/SMD

95%CI

p value

Distant Metastasis

14

0.0

0.903

4.39

2.77–6.95

 < 0.001

Fixed

Significant

Clinical stage

7

0.0

0.635

0.22

2.25–9.55

 < 0.001

Fixed

Significant

MVD

3

78.0

0.011

3.33

1.57–5.10

 < 0.001

Random

Significant

Tumor location

4

0.0

0.828

0.799

0.39–1.63

0.538

Fixed

Not significant

Gender

12

46.2

0.040

0.91

0.53–1.55

0.726

Random

Not significant

Local recurrence

3

0.0

0.522

1.43

0.69–2.98

0.328

Fixed

Not significant

Age

4

5.7

0.290

0.71

0.37–1.34

0.364

Fixed

Not significant

Chemotherapy response

8

36.8

0.135

0.96

0.63–1.45

0.832

Fixed

Not significant

  1. OR, odds ratio CI; confidence interval; SMD, standard mean difference; MVD, microvessel density; VEGF, vascular endothelial growth factor