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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: miR-653-5p suppresses the viability and migration of fibroblast-like synoviocytes by targeting FGF2 and inactivation of the Wnt/beta-catenin pathway

Fig. 5

miR-653-5p regulates HFLS-RA cell viability and metastasis via targeting FGF2. A RT-qPCR determined FGF2 expression in HFLS-RA cells transfected with NC mimics, miR-653-5p mimics, miR-653-5p mimics + pcDNA3.1/FGF2. B–D MTT, wound healing, and transwell assays showed cell viability, migration, and invasion in HFLS-RA cells transfection of NC mimics, miR-653-5p mimics, miR-653-5p mimics + pcDNA3.1/FGF2. E and F Western blot and RT-qPCR assays showed the protein and mRNA expression of Rac1, Cdc42, and RhoA in HFLS-RA cells transfected with NC mimics, miR-653-5p mimics, miR-653-5p mimics + pcDNA3.1/FGF2. *P < 0.05, **P < 0.01

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X