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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway

Fig. 6

MiR-338-3p suppresses MM cell proliferation, angiogenesis and metastasis via ATG14. A–J H929 and MM.1S cells were transfected with miR-NC, miR-338-3p, miR-338-3p + vector, or miR-338-3p + ATG14. Cell proliferation analysis using CCK-8 (A, B), colony formation (C), and EdU assays (D). E Flow cytometry for cell apoptosis. F Tube formation ability of HUVECs cultivated for 6 h in the TCM from transfected H929 and MM.1S cells. G, H Transwell assay for cell migration and invasion. I, J Western blot analysis of the protein levels of E-cadherin, vimentin and N-cadherin. *P < 0.05

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