Fig. 4

Circ_0058058 regulates proliferation, angiogenesis and metastasis in MM cells via miR-338-3p. A–J H929 and MM.1S cells were transfected with si-NC, si-circ_0058058, si-circ_0058058 + anti-miR-NC, or si-circ_0058058 + anti-miR-338-3p. Cell proliferation analysis using CCK-8 (A, B), colony formation (C), and EdU assays (D). E Flow cytometry for cell apoptosis. F Tube formation ability of HUVECs cultivated for 6 h in the TCM from transfected H929 and MM.1S cells. G, H Transwell assay for cell migration and invasion. I, J Western blot analysis of the protein levels of E-cadherin, vimentin and N-cadherin. *P < 0.05