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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Expression of STOML2 promotes proliferation and glycolysis of multiple myeloma cells via upregulating PAI-1

Fig. 5

PAI-1 reverses STOML2 silencing-mediated tumor cell growth inhibition in MM. A PAI-1 reverses shSTOML2-mediated cell proliferation inhibition; B statistical analysis shows that PAI-1 reverses shSTOML2-mediated cell proliferation inhibition; C PAI-1 reverses shSTOML2-mediated increase in Caspase-3 activity; D PAI-1 reverses shSTOML2-mediated decrease in GLUT1, HK2 and LDHA; EG Statistical analyses show that PAI-1 reverses shSTOML2-mediated downregulation of GLUT1 E, HK2 F, and LDHA G. **p < 0.01 vs shNC; @p < 0.05 vs shSTOML2-2# + NC; @@p < 0.01 vs shSTOML2-2# + NC; #p < 0.05 vs PAI-1 + shNC; ##p < 0.05 vs PAI-1 + shNC. PAI-1: pcDNA3.1 plasmid containing full coding sequence of PAI-1; NC: scrambled sequence of PAI-1

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