Fig. 2

Knockdown of STOML2 inhibits MM cell growth. A Protein expression of STOML2 is reduced by shSTOML2-1# and shSTOML2-2# in MM cell lines; B MM cell viability is reduced by shSTOML2-1# and shSTOML2-2#; C the number of cell colonies is reduced by shSTOML2-1# and shSTOML2-2# in MM cell lines; D the activity of Caspase-3 is increased by shSTOML2-1# and shSTOML2-2# in MM cell lines; E the protein expression of Bcl2 and PCNA is downregulated, and the protein expression of Bax and Clv-PARP is upregulated by shSTOML2-1# and shSTOML2-2# in MM cell lines. *p < 0.05 vs shNC; **p < 0.01 vs shNC. shSTOML2: short hairpin RNAs of STOML2; shNC: scrambled RNA of shSTOML2