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Table 2 Comparison of synovial fluid PCR with conventional diagnostic methods from the included studies

From: Meta-analysis of synovial fluid polymerase chain reaction for diagnosing periprosthetic hip and knee infection

Diagnostic method

Number of studies

Sensitivity (95% CI)

Specificity (95% CI)

PLR (95% CI)

NLR (95% CI)

DOR (95% CI)

SROC (SE)

CRP

4

0.67 (0.54–0.78)

0.79 (0.74–0.83)

2.99 (2.01–4.45)

0.49 (0.26–0.92)

7.55 (3.58–15.94)

0.7969 (0.0428)

Synovial fluid PCR

4

0.79 (0.67–0.87)

0.91 (0.88–0.93)

12.05 (2.83–51.30)

0.20 (0.05–0.89)

93.69 (5.10–1721.56)

0.9613 (0.0427)

ESR

3

0.80 (0.67–0.90)

0.68 (0.63–0.73)

2.58 (2.10–3.16)

3.30 (0.17–0.52)

10.16 (4.72–21.85)

0.8284 (0.0391)

Synovial fluid PCR

3

0.93 (0.81–0.99)

0.93 (0.90–0.96)

29.92 (0.53–1678.60)

0.12 (0.01–0.93)

291.64 (12.63–6735.22)

0.9838 (0.0205)

Synovial fluid culture

9

0.70 (0.65–0.75)

0.98 (0.96–0.99)

27.26 (16.94–43.85)

0.28 (0.20–0.40)

115.11 (61.80–214.41)

0.9668 (0.0079)

Synovial fluid PCR

10

0.69 (0.64–0.74)

0.91 (0.89–0.93)

8.21 (4.56–14.77)

0.34 (0.25–0.46)

32.23 (13.94–74.50)

0.9173 (0.0239)

Tissue culture

5

0.70 (0.63–0.75)

0.92 (0.89–0.95)

13.10 (5.51–31.10)

0.30 (0.16–0.54)

41.53 (22.40–76.97)

0.9305 (0.0152)

Synovial fluid PCR

6

0.67 (0.61–0.72)

0.88 (0.85–0.91)

5.45 (3.42–8.68)

0.35 (0.26–0.48)

16.93 (10.65–26.90)

0.8740 (0.0187)

Histology

2

0.75 (0.63–0.85)

1.00 (0.96–1.00)

66.59 (9.47–468.05)

0.22 (0.07–0.69)

325.27 (24.60–4300.37)

NA

Synovial fluid PCR

2

0.64 (0.53–0.74)

0.81 (0.73–0.87)

4.17 (2.28–7.62)

0.29 (0.06–1.29)

14.20 (6.17–32.66)

NA

Sonicate fluid culture

3

0.75 (0.67–0.82)

0.96 (0.90–0.99)

11.97 (2.89–49.52)

0.26 (0.13–0.53)

50.95 (9.26–280.39)

0.9397 (0.0371)

Synovial fluid PCR

4

0.65 (0.59–0.71)

0.90 (0.86–0.93)

6.06 (4.29–8.57)

0.37 (0.26–0.53)

15.37 (9.49–24.87)

0.8662 (0.0203)

  1. CI, confidential interval; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; PCR, polymerase chain reaction; PLR, positive likelihood ratio; NA, not available; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; SROC, Summary receiver operating characteristic; SE, standard error