Fig. 1

RNA sequencing analysis determined the circRNAs expression profiles and Identification the characterization of circRNAs. (a–c) Heat map of differentially expressed circRNAs in four RA patients and four healthy controls with age and gender matched (a), two RA female patients and two healthy female controls (b), two RA female patients and two RA male patients (c); ‘Red’ indicates high relative expression, and ‘Green’ indicates low relative expression. (d) Venn diagram analysis of three RNA-seq cohort (RA vs HC; RA female vs HC female; RA female vs RA male). (e) Sanger sequencing for hsa_circ_0140271. (f) Relative expression of hsa_circ_0140271 and mRNA of MED14 in PBMC from RA patients treated with or without RNase R