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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: Doxorubicin inhibits osteosarcoma progression by regulating circ_0000006/miR-646/ BDNF axis

Fig. 7

MiR-646 mimic facilitated OS sensitivity to DOX through binding to BDNF. A Cell viability assay was performed to determine the effects between miR-646 mimic and BDNF overexpression on cell viability after DOX exposure in U2OS and SJSA1 cells. B, C, E Transwell migration and wound-healing assays and transwell invasion assay were performed to unveil the impacts between miR-646 mimic and enforced BDNF expression on cell migration and invasion, respectively, under DOX treatment in U2OS and SJSA1 cells. D The effects between miR-646 and BDNF overexpression on cell colony-forming ability after DOX exposure were revealed by cell colony formation assay in U2OS and SJSA1 cells. F Flow cytometry analysis was carried out to explain the influences between miR-646 and BDNF on the apoptosis of U2OS and SJSA1 cells after DOX treatment. *P < 0.05

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