Table 2 KEGG signaling pathways regulated by important targets
Category | Pathway | Number of genes | Mapped targets | FDR |
|---|---|---|---|---|
Endocrine system | Estrogen signaling pathway | 99 | 12 | 8.91 × 10–7 |
Signal transduction | HIF-1 signaling pathway | 96 | 10 | 4.82 × 10–5 |
Signal transduction | VEGF signaling pathway signaling pathway | 61 | 8 | 1.33 × 10–4 |
Signal transduction | TNF signaling pathway | 107 | 9 | 4.21 × 10–4 |
Signal transduction | Ras signaling pathway | 226 | 12 | 5.69 × 10–4 |
Signal transduction | FoxO signaling pathway | 134 | 9 | 0.001 |
Signal transduction | MAPK signaling pathway | 253 | 12 | 0.001 |
Signal transduction | PI3K-Akt signaling pathway | 345 | 14 | 0.001 |
Development and regeneration | Osteoclast differentiation | 131 | 8 | 0.004 |
Sensory system | Inflammatory mediator regulation of TRP channels | 98 | 7 | 0.004 |