Fig. 3
From: MiR-4303 relieves chondrocyte inflammation by targeting ASPN in osteoarthritis
MiR-4303 overexpression inhibited the release of inflammatory factors from LPS-treated chondrocytes. Chondrocytes were randomly divided into four groups, control group; chondrocytes were untreated; LPS group, 1 × 105 chondrocytes were treated with 10 μL LPS (100 ng/mL); NC mimic + LPS group, 1 × 105 chondrocytes were treated with 10 μL LPS (100 ng/mL) and 100 nM NC mimics; miR-4303 mimic + LPS group, 1 × 105 chondrocytes were treated with 10 μL LPS (100 ng/ml) and 100 nM miR-4303 mimics. Untreated chondrocytes served as the negative control for LPS-treated chondrocytes; NC mimics served as the negative control for miR-4303 mimics. A The levels of TNF-α in the supernatant of chondrocytes. B The levels of IL-β in the supernatant of chondrocytes. C The levels of IL-6 in the supernatant of chondrocytes. Tukey post-test was used for comparison between multiple groups. **P < 0.01 versus control group; #P < 0.05, ##P < 0.01 versus NC mimic + LPS group. Error bars represented SD. Data represented three independent experiments