Association between polymorphisms of collagen genes and susceptibility to intervertebral disc degeneration: a meta-analysis

Table 4 Association between Trp2/3 polymorphisms and disc degeneration susceptibility

Polymorphism	No. of studies	Sample size (case/control)	Pooled effect size		Heterogeneity
Polymorphism	No. of studies	Sample size (case/control)	OR (95% CI)	P	I² (%)	P
COL9A2 Trp2, rs137853213
Overall	14	2187/1987	1.43 (0.99–2.06)	0.058	64.1	< 0.001
Ethnicity
Caucasian	4	416/531	2.62 (1.15–6.01)	0.022	18.6	0.298
Asian	8	1649/1439	1.35 (0.89–2.04)	0.154	77.7	< 0.001
Mixed	2	122/17	0.97 (0.11–8.86)	0.977	0	0.966
Gender
Male	3	179/142	3.00 (1.57–5.74)	0.001	41.2	0.182
COL9A3 Trp3, rs61734651
Overall	11	1075/1296	1.28 (0.81–2.02)	0.299	60.5	0.005
Ethnicity
Caucasian	7	745/1122	1.31 (0.71–2.41)	0.390	74.7	< 0.001
Asian	2	208/157	1.30 (0.68–2.50)	0.422	34.7	0.216
Mixed	2	122/17	1.60 (0.26–9.88)	0.615	0	0.938
Gender
Male	6	286/268	1.12 (0.42–2.97)	0.827	55.7	0.046
Female	5	195/207	1.11 (0.62–2.01)	0.725	0	0.802

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