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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Adipogenic differentiation was inhibited by downregulation of PPARγ signaling pathway in aging tendon stem/progenitor cells

Fig. 4

The adipogenesis of aging TSCs was inhibited through downregulating PPARγ signaling pathway. A western blot analysis of the adipogenic markers after adding 4 different concentration of Rosiglitazone maleate (RM) in aging TSPCs for 2 weeks. B Oil red O staining of young (B1), aging (B2) and aging with RM (B3) TSPCs, (B4) The lipid droplets increased in aging TSPCs with RM. C The expression of Perilipin, PPARγ and Slc27a6 in young, aging and aging with RM TSPCs. (B1) The decreased expression of Perilipin, PPARγ and Slc27a6 were reversed after adding the specific agonist of PPARγ pathway RM. (B2) Quantitative analysis of the Western blot results. Black bar: 100 μm. *p < .05; **p < .01; ***p < .001. These experiments were repeated for 5 times

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X