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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Downregulation of miR-1-3p expression inhibits the hypertrophy and mineralization of chondrocytes in DDH

Fig. 3

Downregulation of miR-1-3p expression suppresses chondrocyte hypertrophy and reduces mineralization. A FISH was used to verify miR-1-3p expression in rabbit and human chondrocytes (a). Scale bar: 100 μm. B Introduction of the miR-1-3p inhibitor successfully downregulated miR-1-3p levels in human chondrocytes. C ARS staining of the miR-1-3p-downregulated chondrocytes exhibiting reduced mineralization compared to the controls. Scale bar: 200 μm. D, E Reduced RUNX2 and collagen type X levels in the miR-1-3p-silenced chondrocytes versus the controls. (*P < 0.05, **P < 0.01)

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