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Table 1  Reported Cases

From: Minocycline black bone disease in arthroplasty: a systematic review

Study

Age

Joint

Indication

Fixation

Components

Subchondral bone

Minocycline dose (cumulative, g)

Follow-up (years)

Outcome—pain

Outcome—function

Ashukem et al. (2016)

Not noted

Primary shoulder

OA

Uncemented stem, cemented glenoid

Press-fit humeral stem, cemented pegged glenoid (DJO Turon)

Greyish-black

Unspecified

0.5

Little to no pain

Normal ADLs, return of ROM, stable shoulder

Chauhan and McDougall (2014)

82

Primary knee (bilateral)

OA

  

Black, normal cancellous bone

    

McCleskey and Littleton (2004)

81

Primary knee (right)

OA

Cemented

Unspecified

Blue-green-grey

~73

1

 

Return of ROM, stable knee

Reed, Gregg, and Corpe (2012)

55

Primary knee (left)

OA

Cemented

Not noted, patella not resurfaced

Black, normal cancellous bone

> 365

0.25

No pain

Normal ADLs, return of ROM, stable knee

Yang et al. (2012)

75

Primary ankle

Reactive arthritis

 

Fine total ankle

Black

140

4.6

Occasional arthritic pain

Normal ADLs

 

49

Primary knee

RA

 

Biomet Vanguard

Black

131

2.8

No pain

Normal ADLs

 

77

Revision knee

OA

 

Zimmer Nexgen LCCK

Black

176

2

Not noted—multiple cerebral infarctions at 2 years

 

48

Primary hip

RA

 

Zimmer ZCA cup and CPT stem

Black

94.3

3.8

No pain

Normal ADLs

 

33

Revision hip

Sarcoidosis

 

Zimmer ZCA cup with JMM KT plate, Zimmer CPT stem

Black

42.5

3.6

No pain

Normal ADLs

This study (2021)

57

Primary knee (right)

OA

Cemented

Stryker Triathlon PS, patella resurfaced

Black

584

4

No pain

Normal ADLs, return of ROM, stable knee

 

59

Primary knee (left)

OA

Cemented

Stryker Triathlon CR, patella not resurfaced

Black

621

2

No pain

Normal ADLs, return of ROM, stable knee