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Table 1  Reported Cases

From: Minocycline black bone disease in arthroplasty: a systematic review

Study Age Joint Indication Fixation Components Subchondral bone Minocycline dose (cumulative, g) Follow-up (years) Outcome—pain Outcome—function
Ashukem et al. (2016) Not noted Primary shoulder OA Uncemented stem, cemented glenoid Press-fit humeral stem, cemented pegged glenoid (DJO Turon) Greyish-black Unspecified 0.5 Little to no pain Normal ADLs, return of ROM, stable shoulder
Chauhan and McDougall (2014) 82 Primary knee (bilateral) OA    Black, normal cancellous bone     
McCleskey and Littleton (2004) 81 Primary knee (right) OA Cemented Unspecified Blue-green-grey ~73 1   Return of ROM, stable knee
Reed, Gregg, and Corpe (2012) 55 Primary knee (left) OA Cemented Not noted, patella not resurfaced Black, normal cancellous bone > 365 0.25 No pain Normal ADLs, return of ROM, stable knee
Yang et al. (2012) 75 Primary ankle Reactive arthritis   Fine total ankle Black 140 4.6 Occasional arthritic pain Normal ADLs
  49 Primary knee RA   Biomet Vanguard Black 131 2.8 No pain Normal ADLs
  77 Revision knee OA   Zimmer Nexgen LCCK Black 176 2 Not noted—multiple cerebral infarctions at 2 years
  48 Primary hip RA   Zimmer ZCA cup and CPT stem Black 94.3 3.8 No pain Normal ADLs
  33 Revision hip Sarcoidosis   Zimmer ZCA cup with JMM KT plate, Zimmer CPT stem Black 42.5 3.6 No pain Normal ADLs
This study (2021) 57 Primary knee (right) OA Cemented Stryker Triathlon PS, patella resurfaced Black 584 4 No pain Normal ADLs, return of ROM, stable knee
  59 Primary knee (left) OA Cemented Stryker Triathlon CR, patella not resurfaced Black 621 2 No pain Normal ADLs, return of ROM, stable knee