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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Circ_0025908 regulates cell vitality and proliferation via miR-137/HIPK2 axis of rheumatic arthritis

Fig. 2

Circ_0025908 knockdown inhibited RA progression. (A) The silencing efficiency of circ_0025908 was measured by qRT-PCR. (B) CCK8 assay was applied to evaluate the cell viability cells. (C) The EdU positive cell was detected by EdU assay. (D) Flow cytometry assay was carried out to explain the cell mitotic cycle. (E) The protein level of Ki67 and PCNA was examined by western blot. (F) Flow cytometry assay was employed to explain the apoptosis of RA cells. (G) The protein level of Bax and Bcl-2 were examined by western blot. (H-J) The level of IL-1β, IL-6, and TNF-α were measured by ELISA. (K) The protein levels of p-NF-KB p65 and total-NF-KB p65 were examined by western blot. *P < 0.05

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