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Table 2 The meta-analysis of the rate of adverse events of IGU monotherapy or combined therapy

From: Effectiveness of iguratimod as monotherapy or combined therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis of RCTs

Adverse reaction Comparison Studies, n Participants, n OR (95% CI), P value Test of heterogeneity
Cochran Q, df, P value, I2
(Drug 1 vs. Drug 2) Drug 1 Drug 2  
Gastrointestinal reactions IGU vs. MTX 7 356 359 OR = 0.69 (0.40, 1.04), P= 0.070 Cochran Q = 1.46, df = 6, P = 0.962, I2 = 0.0%
  IGU+MTX vs. MTX 13 540 534 OR = 0.98 (0.64, 1.51), P = 0.921 Cochran Q = 5.72, df = 12, P = 0.929, I2 = 0.0%
  IGU+Other drugs vs. Other drugs 2 83 84 OR = 1.43 (0.28, 7.45), P = 0.670 Cochran Q = 0.36, df = 1, P = 0.547, I2 = 0.0%
Leucopenia IGU vs. MTX 8 406 409 OR = 0.69 (0.34, 1.40), P = 0.309 Cochran Q = 3.39, df = 7, P = 0.846, I2 = 0.0%
  IGU+MTX vs. MTX 10 408 402 OR = 0.93 (0.48, 1.80), P = 0.838 Cochran Q = 2.03, df = 9, P = 0.991, I2 = 0.0%
Increment in transaminase IGU vs. MTX 2 52 58 OR = 2.7 (0.38, 19.09), P = 0.321 Cochran Q = 0.01, df = 1, P = 0.906, I2 = 0.0%
  IGU+MTX vs. MTX 5 204 201 OR = 1.90 (0.72, 4.99), P = 0.193 Cochran Q = 1.12, df = 4, P = 0.891, I2=0.0%
  IGU+Other drugs vs. Other drugs 1 54 54 OR = 0.33 (0.01, 8.21), P = 0.497 Cochran Q = 0.0, df = 0
Increase of ALT IGU vs. MTX 3 249 247 OR = 0.61 (0.38, 1.00), P = 0.051 Cochran Q = 1.95, df = 2, P = 0.376, I2 = 0.0%
  IGU+MTX vs. MTX 3 249 172 OR = 0.99 (0.50, 1.97), P = 0.985 Cochran Q = 1.08, df = 2, P = 0.583, I2 = 0.0%
Liver damage IGU vs. MTX 1 30 30 OR = 0.13 (0.01, 2.61), P = 0.182 Cochran Q = 0.0, df = 0
  IGU+MTX vs. MTX 3 129 129 OR = 0.32 (0.07, 1.36), P = 0.123 Cochran Q = 0.00, df = 2, P = 1.000, I2 = 0.0%
Other adverse reactions IGU vs. MTX 5 304 301 OR = 0.56 (0.33, 0.95), P = 0.032 Cochran Q = 1.14, df = 4, P = 0.888, I2 = 0.0%
  IGU+MTX vs. MTX 12 614 532 OR = 2.42 (1.56, 3.77), P < 0.001 Cochran Q = 17.74, df = 11, P = 0.088, I2 = 38.0%
  IGU+Other drugs vs. Other drugs 2 83 84 OR = 1.02 (0.14, 7.42), P = 0.986 Cochran Q = 0.00, df = 1, P = 0.986, I2 = 0.0%
  1. IGU iguratimod, MTX methotrexate, OR odd ratio