Adverse reaction | Comparison | Studies, n | Participants, n | OR (95% CI), P value |
Test of heterogeneity Cochran Q, df, P value, I^{2} | |
---|---|---|---|---|---|---|
(Drug 1 vs. Drug 2) | Drug 1 | Drug 2 | ||||
Gastrointestinal reactions | IGU vs. MTX | 7 | 356 | 359 | OR = 0.69 (0.40, 1.04), P= 0.070 | Cochran Q = 1.46, df = 6, P = 0.962, I^{2} = 0.0% |
IGU+MTX vs. MTX | 13 | 540 | 534 | OR = 0.98 (0.64, 1.51), P = 0.921 | Cochran Q = 5.72, df = 12, P = 0.929, I^{2} = 0.0% | |
IGU+Other drugs vs. Other drugs | 2 | 83 | 84 | OR = 1.43 (0.28, 7.45), P = 0.670 | Cochran Q = 0.36, df = 1, P = 0.547, I^{2} = 0.0% | |
Leucopenia | IGU vs. MTX | 8 | 406 | 409 | OR = 0.69 (0.34, 1.40), P = 0.309 | Cochran Q = 3.39, df = 7, P = 0.846, I^{2} = 0.0% |
IGU+MTX vs. MTX | 10 | 408 | 402 | OR = 0.93 (0.48, 1.80), P = 0.838 | Cochran Q = 2.03, df = 9, P = 0.991, I^{2} = 0.0% | |
Increment in transaminase | IGU vs. MTX | 2 | 52 | 58 | OR = 2.7 (0.38, 19.09), P = 0.321 | Cochran Q = 0.01, df = 1, P = 0.906, I^{2} = 0.0% |
IGU+MTX vs. MTX | 5 | 204 | 201 | OR = 1.90 (0.72, 4.99), P = 0.193 | Cochran Q = 1.12, df = 4, P = 0.891, I^{2}=0.0% | |
IGU+Other drugs vs. Other drugs | 1 | 54 | 54 | OR = 0.33 (0.01, 8.21), P = 0.497 | Cochran Q = 0.0, df = 0 | |
Increase of ALT | IGU vs. MTX | 3 | 249 | 247 | OR = 0.61 (0.38, 1.00), P = 0.051 | Cochran Q = 1.95, df = 2, P = 0.376, I^{2} = 0.0% |
IGU+MTX vs. MTX | 3 | 249 | 172 | OR = 0.99 (0.50, 1.97), P = 0.985 | Cochran Q = 1.08, df = 2, P = 0.583, I^{2} = 0.0% | |
Liver damage | IGU vs. MTX | 1 | 30 | 30 | OR = 0.13 (0.01, 2.61), P = 0.182 | Cochran Q = 0.0, df = 0 |
IGU+MTX vs. MTX | 3 | 129 | 129 | OR = 0.32 (0.07, 1.36), P = 0.123 | Cochran Q = 0.00, df = 2, P = 1.000, I^{2} = 0.0% | |
Other adverse reactions | IGU vs. MTX | 5 | 304 | 301 | OR = 0.56 (0.33, 0.95), P = 0.032 | Cochran Q = 1.14, df = 4, P = 0.888, I^{2} = 0.0% |
IGU+MTX vs. MTX | 12 | 614 | 532 | OR = 2.42 (1.56, 3.77), P < 0.001 | Cochran Q = 17.74, df = 11, P = 0.088, I^{2} = 38.0% | |
IGU+Other drugs vs. Other drugs | 2 | 83 | 84 | OR = 1.02 (0.14, 7.42), P = 0.986 | Cochran Q = 0.00, df = 1, P = 0.986, I^{2} = 0.0% |