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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice

Fig. 2

Ex vivo CFU harvested from bone/joint tissue specimens and implants from older and younger mice. On day 28 after the intravenous bacterial inoculation, mice were euthanized, and ex vivo CFU were isolated from bone/joint homogenates and from sonicated implants from the operative (op) and non-operative (non-op) legs of older and younger mice (n = 19–21 mice/group). ac Ex vivo CFU from older mice (a), younger mice (b), and implant specimens (c). df Percentage of mice with the presence or absence of bacteria growth after 48 h of additional culture of bone/tissue homogenates of older mice (d), younger mice (e), and implant specimens (f). g Euler diagram depicting the number of mice on day 28 with and/or without detectable ex vivo CFU from the bone/joint tissue, implant specimens and broth cultures. *P < 0.05, †P < 0.01, and ‡P < 0.001, between op versus non-op bone/joint tissue specimens (a, b) or older versus younger mice (c) as calculated by 2-tailed Mann-Whitney U test or between the percentage of specimens with or without bacterial growth, as calculated by 2-tailed Fischer’s exact test (dg). n.s. not significant

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