|
Characteristic
|
Incident OA (n = 102)
|
Non-incident OA (n = 496)
|
Crude OR (95% CI)
|
P value
|
Adjusted OR (model 1) (95% CI)
|
P value
|
Adjusted OR (model 2) (95% CI)
|
P value
|
|---|
|
Baseline socio-demographic, BMI, and history of knee injury
|
|
Agea
|
61.15 ± 6.37
|
58.77 ± 6.54
|
1.053 (1.021-1.087)
|
<0.01
|
1.067 (1.032-1.102)
|
<0.01
|
1.079 (1.042-1.117)
|
<0.01
|
|
Gendera
| | | | | | | | |
|
Male
|
31 (30.4%)
|
186 (37.5%)
|
1.0 (reference)
| |
1.0 (reference)
| |
1.0 (reference)
| |
|
Female
|
71 (69.6%)
|
310 (62.5%)
|
1.373 (0.867-2.174)
|
0.177
|
1.815 (1.111-2.964)
|
0.017
|
1.756 (1.071-2.877)
|
0.025
|
|
BMIa
| | | | | | | | |
|
Normal
|
35 (34.3%)
|
224 (45.25%)
|
1.0 (reference)
| |
1.0 (reference)
| | | |
|
Overweight
|
60 (58.8%)
|
225 (45.4%)
|
1.699 (1.076-2.682)
|
0.023
|
2.072 (1.278-3.358)
|
0.003
|
2.086 (1.286-3.385)
|
<0.01
|
|
Obesity
|
7 (6.9%)
|
47 (9.5%)
|
0.940 (0.394-2.246)
|
1.118
|
0.459 (0.459-2.742)
|
0.806
|
1.158 (0.474-2.831)
|
0.747
|
|
History of knee injurya
| | | | | | | | |
|
No
|
97 (95.1%)
|
471 (95%)
|
1.0 (reference)
| |
1.0 (reference)
| |
1.0 (reference)
| |
|
Yes
|
5 (4.9%)
|
25 (5%)
|
0.961 (0.359-2.572)
|
0.937
|
0.983 (0.364-2.652)
|
0.973
|
1.038 (0.381-2.829)
|
0.942
|
|
Educationa
| | | | | | | | |
|
Primary school
|
19 (18.6%)
|
117 (23.6%)
|
1.0 (reference)
| |
1.0 (reference)
| |
1.0 (reference)
| |
|
Middle school or above
|
83 (81.4%)
|
379 (76.4%)
|
1.351 (0.787-2.319)
|
0.275
|
1.320 (0.764-2.283)
|
0.32
|
1.329 (0.764-2.313)
|
0.314
|
|
Baseline physical function of the knee
|
|
Range of motionb
|
128.27 ± 7.10
|
129.95 ± 6.46
|
0.955 (0.930-0.981)
|
<0.01
|
0.954 (0.928-0.981)
|
<0.01
|
0.952 (0.923-0.983)
|
<0.01
|
|
Flexion contractureb
|
1.46 ± 2.86
|
1.19 ± 2.15
|
1.071 (0.999-1.147)
|
0.052
|
1.072 (0.998-1.151)
|
0.058
|
1.068 (0.993-1.150)
|
0.078
|
|
50-foot walk testb
|
13.14 ± 2.86
|
12.58 ± 2.57
|
1.081 (1.003-1.164)
|
0.041
|
1.002 (0.941-1.11)
|
0.601
|
1.032 (0.950-1.122)
|
0.452
|
|
Chair stand testa
|
8.82 ± 2.13
|
8.37 ± 2.20
|
1.087 (0.994-1.188)
|
0.066
|
1.056 (0.962-1.159)
|
0.252
|
1.056 (0.960-1.161)
|
0.265
|
|
Baseline knee joint condition in knee level
|
|
Baseline K/L gradeb
| | | | | | | | |
|
0
|
90 (44.1%)
|
831 (83.8%)
|
1.0 (reference)
| |
1.0 (reference)
| |
1.0 (reference)
| |
|
1
|
114 (55.9%)
|
161 (16.2%)
|
8.769 (5.905-13.022)
|
<0.01
|
8.552 (5.575-13.120)
|
<0.01
|
8.527 (5.489-13.246)
|
<0.01
|
|
Baseline knee painb
| | | | | | | | |
|
No
|
179 (87.7%)
|
900 (90.7%)
|
1.0 (reference)
| |
1.0 (reference)
| |
1.0 (reference)
| |
|
Yes
|
25 (12.3%)
|
92 (9.3%)
|
1.646 (0.970-2.793)
|
0.065
|
1.560 (0.903-2.694)
|
0.111
|
1.541 (0.848-2.800)
|
0.156
|
|
Contralateral knee painb
| | | | | | | | |
|
No
|
179 (87.7%)
|
900 (90.7%)
|
1.0 (reference)
| |
1.0 (reference)
| |
1.0 (reference)
| |
|
Yes
|
25 (12.3%)
|
92 (9.3%)
|
0.960 (0.504-1.831)
|
0.902
|
0.770 (0.383-1.546)
|
0.462
|
0.735 (0.361-1.496)
|
0.395
|
- Model 1: Adjusting for age and gender
- Model 2: Adjusting for age, gender, BMI, education and history of injury
- aTested by Generalized Linear Model in patient level
- bTested by Generalized Estimating Equation in knee level
