Skip to main content

Table 5 Subgroup analysis of overall survival of circRNAs in osteosarcoma

From: Clinicopathologic significance and prognostic value of circRNAs in osteosarcoma: a systematic review and meta-analysis

Subgroup

Number of studies

Number of patients

Effect size

Heterogeneity

HR

95%CI

p value

I-square (%)

chi-square (p)

Overall

36

3300

2.437

2.224–2.670

< 0.001

0.0%

0.992

Regulation pattern

      

0.400

Upregulated

30

1823

2.473

2.243–2.726

< 0.001

0.0%

0.998

Downregulated

6

390

2.192

1.684–2.853

< 0.001

11.3%

0.343

Sample size

      

0.572

≥ 53 samples

18

1411

2.390

2.133–2.678

< 0.001

0.0%

0.806

< 53 samples

18

802

2.525

2.166–2.943

< 0.001

0.0%

0.994

Data availability

      

0.235

Reported

12

915

2.488

2.209–2.801

< 0.001

0.0%

0.758

K-M curve

7

380

1.882

1.442–2.457

< 0.001

0.0%

0.933

K-M curve (p)

14

734

2.589

2.144–3.126

<0.001

0.0%

0.991

K-M curve (HR)

3

184

2.624

1.769–3.891

< 0.001

0.0%

0.807

Cutoff value

      

0.482

Median

19

1180

2.279

1.976–2.629

< 0.001

0.0%

0.992

Average

6

391

2.506

1.930–3.256

< 0.001

0.0%

0.797

Other

11

642

2.566

2.245–2.932

< 0.001

0.0%

0.684

NOS score

      

0.903

≥ 5.5 stars

18

1231

2.457

2.097–2.879

< 0.001

0.0%

0.998

< 5.5 stars

18

982

2.427

2.171–2.714

< 0.001

0.0%

0.715

  1. CI confidence interval, HR hazard ratio, K-M curve Kaplan-Meier curve, NOS Newcastle-Ottawa Scale