Subgroup | Number of studies | Number of patients | Effect size | Heterogeneity | |||
---|---|---|---|---|---|---|---|
HR | 95%CI | p value | I-square (%) | chi-square (p) | |||
Overall | 36 | 3300 | 2.437 | 2.224–2.670 | < 0.001 | 0.0% | 0.992 |
Regulation pattern | Â | Â | Â | Â | Â | Â | 0.400 |
Upregulated | 30 | 1823 | 2.473 | 2.243–2.726 | < 0.001 | 0.0% | 0.998 |
Downregulated | 6 | 390 | 2.192 | 1.684–2.853 | < 0.001 | 11.3% | 0.343 |
Sample size | Â | Â | Â | Â | Â | Â | 0.572 |
≥ 53 samples | 18 | 1411 | 2.390 | 2.133–2.678 | < 0.001 | 0.0% | 0.806 |
< 53 samples | 18 | 802 | 2.525 | 2.166–2.943 | < 0.001 | 0.0% | 0.994 |
Data availability | Â | Â | Â | Â | Â | Â | 0.235 |
Reported | 12 | 915 | 2.488 | 2.209–2.801 | < 0.001 | 0.0% | 0.758 |
K-M curve | 7 | 380 | 1.882 | 1.442–2.457 | < 0.001 | 0.0% | 0.933 |
K-M curve (p) | 14 | 734 | 2.589 | 2.144–3.126 | <0.001 | 0.0% | 0.991 |
K-M curve (HR) | 3 | 184 | 2.624 | 1.769–3.891 | < 0.001 | 0.0% | 0.807 |
Cutoff value | Â | Â | Â | Â | Â | Â | 0.482 |
Median | 19 | 1180 | 2.279 | 1.976–2.629 | < 0.001 | 0.0% | 0.992 |
Average | 6 | 391 | 2.506 | 1.930–3.256 | < 0.001 | 0.0% | 0.797 |
Other | 11 | 642 | 2.566 | 2.245–2.932 | < 0.001 | 0.0% | 0.684 |
NOS score | Â | Â | Â | Â | Â | Â | 0.903 |
≥ 5.5 stars | 18 | 1231 | 2.457 | 2.097–2.879 | < 0.001 | 0.0% | 0.998 |
< 5.5 stars | 18 | 982 | 2.427 | 2.171–2.714 | < 0.001 | 0.0% | 0.715 |