Clinicopathologic significance and prognostic value of circRNAs in osteosarcoma: a systematic review and meta-analysis

Zhong, Jingyu; Zhang, Guangcheng; Yao, Weiwu

doi:10.1186/s13018-021-02568-2

Journal of Orthopaedic Surgery and Research

Table 1 Characteristics of included studies

From: Clinicopathologic significance and prognostic value of circRNAs in osteosarcoma: a systematic review and meta-analysis

Author	Year	CircRNA	Regulation pattern	Country	Sample size	Specimen	Method	Outcome	NOS
Chen	2021	circ_0000885	Upregulated	China	30	Tissue	qRT-PCR	CP	5
Ding	2020	circ_0005909	Upregulated	China	54	Tissue	qRT-PCR	CP, OS	5
Gao	2020	circ_0001721	Upregulated	China	56	Tissue	qRT-PCR	CP, OS	4
Hu	2020	circLARP4	Downregulated	China	72	Tissue	qRT-PCR	CP, DFS, OS	6
Huang	2018	circNASP	Upregulated	China	39	Tissue	qRT-PCR	CP	6
Ji	2020	circ_001621	Upregulated	China	30	Tissue	qRT-PCR	CP, OS	6
Jiang	2020	circXPO1	Upregulated	China	52	Tissue	qRT-PCR	DFS, OS	5
Jiang	2021	circ_0000658	Downregulated	China	60	Tissue	qRT-PCR	CP, OS	4
Jin	2019A	circ_0102049	Upregulated	China	76	Tissue	qRT-PCR	CP, OS	5
Jin	2019B	circ_100876	Upregulated	China	48	Tissue	qRT-PCR	CP, OS	5
Jin	2019C	circ_0002052	Downregulated	China	46	Tissue	qRT-PCR	CP, OS	6
Lei	2020	circ_0003074	Upregulated	China	60	Tissue	qRT-PCR	CP, DFS, OS	6
Li	2018	circ_0007534	Upregulated	China	57	Tissue	qRT-PCR	CP, OS	6
Li	2019	circ_0001721	Upregulated	China	52	Tissue	qRT-PCR	CP, OS	6
Li	2020A	circ_0000073	Upregulated	China	25	Tissue	qRT-PCR	OS	5
Li	2020B	circ 0003732	Upregulated	China	46	Tissue	qRT-PCR	CP, OS	4
Li	2020C	circ_0000190	Downregulated	China	60	Tissue	qRT-PCR	CP	6
Liu	2020	circ_100284	Upregulated	China	52	Tissue	qRT-PCR	CP, OS	4
Liu	2021A	circ_0105346	Upregulated	China	40	Tissue	qRT-PCR	CP, OS	6
Liu	2021B	circMTO1	Downregulated	China	70	Tissue	qRT-PCR	CP, OS	5
Ma	2018	circHIPK3	Downregulated	China	82	Tissue	qRT-PCR	CP, OS	6
Mao	2021	circXPR1	Upregulated	China	20	Tissue	qRT-PCR	DFS, OS	5
Nie	2018	circNT5C2	Upregulated	China	170	Tissue	qRT-PCR	CP, DFS, OS	7
Pan	2019	circMMP9	Upregulated	China	51	Tissue	qRT-PCR	CP, OS	4
Pan	2020	circ_103801	Upregulated	China	43	Serum	qRT-PCR	CP, OS	3
Qi	2018	circ_0000502	Upregulated	China	63	Tissue	qRT-PCR	CP, OS	6
Wang	2019A	circ_0003998	Upregulated	China	60	Tissue	qRT-PCR	OS	5
Wang	2019B	circ_0002052	Downregulated	China	60	Tissue	qRT-PCR	CP, OS	7
Wang	2019C	circ_0021347	Downregulated	China	35	Tissue	qRT-PCR	OS	3
Wang	2020A	circCNST	Upregulated	China	126	Tissue	qRT-PCR	CP, OS	6
Wang	2020B	circTCF25	Upregulated	China	50	Tissue	qRT-PCR	CP	6
Wang	2020C	circ_0001658	Upregulated	China	39	Tissue	qRT-PCR	CP	6
Wei	2021	circ_0081001	Upregulated	China	63	Tissue	qRT-PCR	OS	5
Wen	2021	circHIPK3	Upregulated	China	12	Tissue	qRT-PCR	OS	3
Wu	2020	circ_0002052	Downregulated	China	54	Tissue	qRT-PCR	PFS, OS	3
Xiang	2020	circ_0005721	Upregulated	China	50	Tissue	qRT-PCR	CP, DFS, OS	8
Yan	2020	circPVT1	Upregulated	China	48	Tissue	qRT-PCR	CP, OS	4
Yang	2020	circ_0001105	Upregulated	China	120	Tissue	qRT-PCR	CP, DFS, OS	5
Zhang	2017	circUBAP2	Upregulated	China	92	Tissue	qRT-PCR	OS	4
Zhang	2018	circ_001569	Upregulated	China	36	Tissue	qRT-PCR	CP	8
Zhang	2019	circ_0051079	Upregulated	China	105	Tissue	qRT-PCR	OS	4
Zhang	2020A	circ_0002052	Upregulated	China	40	Tissue	qRT-PCR	CP, OS	4
Zhang	2020B	circ_0136666	Upregulated	China	47	Tissue	qRT-PCR	OS	3
Zhang	2020C	circ_0017247	Upregulated	China	46	Tissue	qRT-PCR	CP	7
Zhang	2021	circ_0005909	Upregulated	China	30	Tissue	qRT-PCR	CP	7
Zhao	2019	circSAMD4A	Upregulated	China	NR	Tissue	qRT-PCR	OS	3
Zheng	2019	circLRP6	Upregulated	China	50	Tissue	qRT-PCR	DFS, OS	4
Zhou	2017	circ_0008717	Upregulated	China	45	Tissue	qRT-PCR	PFS, OS	6
Zhu	2018A	circPVT1	Upregulated	China	80	Tissue	qRT-PCR	CP, OS	6
Zhu	2018B	circ_0081001	Upregulated	China	82	Tissue	qRT-PCR	CP, OS	7
Zhu	2018C	circ_0004674	Upregulated	China	60	Tissue	qRT-PCR	CP, OS	6
Zhu	2019	circ_0000885	Upregulated	China	50	Tissue	qRT-PCR	CP, DFS, OS	6

CP clinicopathology, DFS disease-free survival, NA not applicable, NOS Newcastle-Ottawa Scale, NR not reported, OS overall survival, PFS progression-free survival, qRT-PCR quantitative real-time polymerase chain reaction

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ISSN: 1749-799X

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