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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Study on the potential active components and molecular mechanism of Xiao Huoluo Pills in the treatment of cartilage degeneration of knee osteoarthritis based on bioinformatics analysis and molecular docking technology

Fig. 3

Bioinformatics analysis of GSE114007. A Box plots of samples before and after normalization, representing the counts distribution of each sample. B PCA plot before and after normalization; each point represents a sample; the farther the distance between the two samples, the greater the difference between the two samples. C Heat map of total 1672 DEGs in GSE114007. D Heat map of top 50 DEGs in GSE114007. Tissue samples are presented as columns; individual genes are presented as rows. Red indicates upregulated genes and green indicates downregulated genes in patients with KOA. The patients in the top rows in pink indicates columns were normals; the patients in the top rows in blue indicates columns were patients with KOA. E The volcano plot of total 1672 DEGs in GSE114007. The vertical blue lines correspond to Log2FC up and down and the horizontal orange line represents an adjusted P value of 0.01. The red point represents the differentially upregulated genes with statistical significance. The green point represents the differentially downregulated genes with statistical significance.

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