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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis

Fig. 6

The influence of miR-140-3p and PPM1A on cell malignant progression and inflammatory response in RA-FLSs. RA-FLSs were transfected with miR-NC, miR-140-3p, miR-140-3p + vector, or miR-140-3p + PPM1A. A Western blot assay was performed to detect the protein expression of PPM1A. Cell proliferation (B), apoptosis (C) and cycle distribution (D), migration (E), and invasion (F) were measured by MTT assay, flow cytometry analysis, or transwell assay, respectively. G Western blot was carried out to examine the protein expression of Bax, Bcl-2, MMP2, and MMP9. H–J The levels of TNF-α, IL-1β, and IL-6 were analyzed by ELISA. *P < 0.05

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