Fig. 8

Circ-SPG11/miR-337-3p/ADAMTS5 axis was associated with OA development. A QRT-PCR was used to detect ADAMTS5 mRNA expression in CHON-001 cells without treatment or treated with IL-1β and transfected with si-circ-SPG11, si-circ-SPG11 + anti-miR-337-3p, or negative controls. B Western blot was applied to measure ADAMTS5 protein expression in CHON-001 cells without treatment or treated with IL-1β and transfected with si-circ-SPG11, si-circ-SPG11 + anti-miR-337-3p, or negative controls. C Schematic diagram described the signal pathway of circ-SPG11/miR-337-3p/ADAMTS5 axis in OA. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001