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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Circ-SPG11 knockdown hampers IL-1β-induced osteoarthritis progression via targeting miR-337-3p/ADAMTS5

Fig. 2

IL-1β regulated CHON-001 cell proliferation, apoptosis, inflammatory cytokines secretion, and ECM degradation. A The cell viability was detected by CCK-8 assay. B, C The flow cytometry assay was assessed to measure the cell apoptosis in CHON-001 cells. D The concentration of inflammatory factors TNF-α and IL-6 was detected by ELISA. E The western blot assay was utilized to analyze the MMP13 and Aggrecan expressions. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X