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Table 4 correlation between protein levels in synovial fluid and clinical and radiographic outcomes 12 months after surgery for ankle fracture (n = 42)

From: Association of acute inflammatory cytokines, fracture malreduction, and functional outcome 12 months after intra-articular ankle fracture—a prospective cohort study of 46 patients with ankle fractures

 

Protein levels

Kellgren-Lawrence score

p value (coef.)

Narrowing in joint space

p value (coef.)

FFI-DK

p value (coef.)

AOFAS

p value (coef.)

EQ5D-5L

p value (coef.)

Pro-inflammatory

IL-1α

IL-1β

0.03 (0.17)

0.02 (0.002)

IL-2

IL-6

0.04 (− 0.0004)

IL-8

IL-12p70

TNF-α

TNF-β

 

IFN-y

0.048 (− 0.01)

MMP-1

MMP-3

MMP-9

Anti-inflammatory

IL-1RA

IL-4

0.03 (− 0.38)

IL-10

IL-13

Cartilage degradation

ACG

CTX2

Metabolic

b-FGF

TGF-β1

TGF-β2

0.009 (− 0.5)

TGF-β3

  1. Coef: coefficient value (ranges from − 1 to 1 and indicates that a change of 1 unit in the variable will result in a change of x units in the outcome score). Only p values below 0.05 are reported
  2. “–” indicates no statistical significance. Adjusted for age, sex, body mass index, and AO fracture classification.