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Table 6 Results of KEGG pathway enrichment analysis of differentially expressed genes (p<0.05)

From: Bioinformatics analysis and identification of genes and molecular pathways in steroid-induced osteonecrosis of the femoral head

Category Term Description Count P value Genes
Upregulated genes hsa05150 Staphylococcus aureus infection 7 0.000000016 CFD, HLA-DRB5, HLA-DMB, FPR1, FPR2, HLA-DRB3, HLA-DRB1
  hsa05140 Leishmaniasis 6 0.000002958 HLA-DRB5, HLA-DMB, NCF1, NCF2, HLA-DRB3, HLA-DRB1
  hsa04612 Antigen processing and presentation 5 0.000103901 HLA-DRB5, HLA-DMB, IFI30, HLA-DRB3, HLA-DRB1
  hsa04145 Phagosome 6 0.000112986 HLA-DRB5, HLA-DMB, NCF1, NCF2, HLA-DRB3, HLA-DRB1
  hsa05310 Asthma 4 0.000125000 HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1
  hsa05332 Graft-versus-host disease 4 0.000166885 HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1
  hsa05330 Allograft rejection 4 0.000235599 HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1
  hsa04940 Type I diabetes mellitus 4 0.000344316 HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1
  hsa04672 Intestinal immune network for IgA production 4 0.000481057 HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1
  hsa05320 Autoimmune thyroid disease 4 0.000648540 HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1
Downregulated genes hsa04068 FoxO signaling pathway 6 0.000398419 GABARAPL2, STK11, GADD45A, AKT2, MAPK1, FOXO3
  hsa04152 AMPK signaling pathway 4 0.020600369 STK11, AKT2, STRADB, FOXO3
  hsa05213 Endometrial cancer 3 0.025486177 AKT2, MAPK1, FOXO3
  hsa04550 Signaling pathways regulating pluripotency of stem cells 4 0.028841590 PCGF5, AKT2, MAPK1, TCF3
  hsa05221 Acute myeloid leukemia 3 0.029250172 AKT2, PIM1, MAPK1
  hsa05223 Non-small cell lung cancer 3 0.029250172 AKT2, MAPK1, FOXO3
  hsa04150 mTOR signaling pathway 3 0.031210886 STK11, AKT2, MAPK1
  hsa05230 Central carbon metabolism in cancer 3 0.037394653 AKT2, SLC2A1, MAPK1
  hsa05211 Renal cell carcinoma 3 0.039552861 AKT2, SLC2A1, MAPK1
  hsa04920 Adipocytokine signaling pathway 3 0.044008403 STK11, AKT2, SLC2A1