Table 6 Results of KEGG pathway enrichment analysis of differentially expressed genes (p<0.05)

Upregulated genes

hsa05150

Staphylococcus aureus infection

7

0.000000016

CFD, HLA-DRB5, HLA-DMB, FPR1, FPR2, HLA-DRB3, HLA-DRB1

hsa05140

Leishmaniasis

6

0.000002958

HLA-DRB5, HLA-DMB, NCF1, NCF2, HLA-DRB3, HLA-DRB1

hsa04612

Antigen processing and presentation

5

0.000103901

HLA-DRB5, HLA-DMB, IFI30, HLA-DRB3, HLA-DRB1

hsa04145

Phagosome

6

0.000112986

HLA-DRB5, HLA-DMB, NCF1, NCF2, HLA-DRB3, HLA-DRB1

hsa05310

Asthma

4

0.000125000

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

hsa05332

Graft-versus-host disease

4

0.000166885

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

hsa05330

Allograft rejection

4

0.000235599

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

hsa04940

Type I diabetes mellitus

4

0.000344316

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

hsa04672

Intestinal immune network for IgA production

4

0.000481057

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

hsa05320

Autoimmune thyroid disease

4

0.000648540

HLA-DRB5, HLA-DMB, HLA-DRB3, HLA-DRB1

Downregulated genes

hsa04068

FoxO signaling pathway

6

0.000398419

GABARAPL2, STK11, GADD45A, AKT2, MAPK1, FOXO3

hsa04152

AMPK signaling pathway

4

0.020600369

STK11, AKT2, STRADB, FOXO3

hsa05213

Endometrial cancer

3

0.025486177

AKT2, MAPK1, FOXO3

hsa04550

Signaling pathways regulating pluripotency of stem cells

4

0.028841590

PCGF5, AKT2, MAPK1, TCF3

hsa05221

Acute myeloid leukemia

3

0.029250172

AKT2, PIM1, MAPK1

hsa05223

Non-small cell lung cancer

3

0.029250172

AKT2, MAPK1, FOXO3

hsa04150

mTOR signaling pathway

3

0.031210886

STK11, AKT2, MAPK1

hsa05230

Central carbon metabolism in cancer

3

0.037394653

AKT2, SLC2A1, MAPK1

hsa05211

Renal cell carcinoma

3

0.039552861

AKT2, SLC2A1, MAPK1

hsa04920

Adipocytokine signaling pathway

3

0.044008403

STK11, AKT2, SLC2A1