Skip to main content

Table 5 The significant terms identified by GO enrichment analysis for the downregulated DEGs in necrosis of the femoral head samples (p<0.05)

From: Bioinformatics analysis and identification of genes and molecular pathways in steroid-induced osteonecrosis of the femoral head

Category

Term

Description

Count

P-value

Genes

BP

GO:0007050

Cell cycle arrest

5

0.002699248

STK11, CDKN2C, GADD45A, STRADB, PA2G4

 

GO:0071456

Cellular response to hypoxia

4

0.007223815

BNIP3L, RGCC, FOXO3, AQP1

 

GO:0032147

Activation of protein kinase activity

3

0.014701889

STK11, RGCC, STRADB

 

GO:0006914

Autophagy

4

0.017407385

GABARAPL2, STK11, MAP1LC3B, OPTN

 

GO:0006417

Regulation of translation

3

0.019332720

AKT2, PA2G4, FOXO3

 

GO:0071474

Cellular hyperosmotic response

2

0.024406307

YBX3, AQP1

 

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

3

0.026857056

TFDP1, RGCC, GADD45A

 

GO:0006915

Apoptotic process

7

0.028790620

KANK2, GADD45A, AKT2, SIAH2, PIM1, MAPK1, SUDS3

 

GO:0031659

Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr

2

0.032410549

RGCC, PIM1

 

GO:0016236

Macroautophagy

3

0.039024308

GABARAPL2, MAP1LC3B, OPTN

CC

GO:0005829

Cytosol

31

0.000004220

SLC2A1, PCTP, HBD, FOXO3, SNX3, STK11, MAP1LC3B, PNP, ...

 

GO:0005737

Cytoplasm

38

0.000058040

KANK2, WDR26, ZFAND5, FOXO3, YBX3, TPGS2, TRAK2, AQP1, ...

 

GO:0005634

Nucleus

33

0.007200508

DCUN1D1, FOXO3, YBX3, DPCD, TRAK2, AQP1, STK11, PNP, ...

 

GO:0005769

Early endosome

5

0.013450748

SNX3, AKT2, SIAH2, MAPK1, TRAK2

 

GO:0005739

Mitochondrion

12

0.016407951

KANK2, BNIP3L, ARG2, STK11, MAP1LC3B, TFDP1, BSG, C10ORF10, ...

 

GO:0005776

Autophagosome

3

0.027193553

GABARAPL2, MAP1LC3B, OPTN

 

GO:0005667

Transcription factor complex

4

0.042391936

HES6, TFDP1, TCF3, PBX1

 

GO:0070062

Extracellular exosome

18

0.049903125

ST13, AKR1C1, SLC2A1, CYBRD1, PA2G4, BPGM, PTPRF, AQP1, ...

MF

GO:0005515

Protein binding

57

0.000001107

ZFAND5, SLC2A1, CISD2, PCTP, HBD, AQP1, STK11, MAP1LC3B, ...

 

GO:0008134

Transcription factor binding

6

0.006463884

HES6, TFDP1, PIM1, MAPK1, TCF3, PBX1

 

GO:0001227

Transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding

3

0.024911797

HES6, FOXO3, YBX3

 

GO:0003677

DNA binding

13

0.041407275

HES6, ZFAND5, PA2G4, FOXO3, KLF3, YBX3, PBX1, TFDP1, ...

 

GO:0003700

Transcription factor activity, sequence-specific DNA binding

9

0.044742463

HES6, TFDP1, TCF3, PA2G4, SOX6, FOXO3, YBX3, KLF3, ...